公开(公告)号：US20210206843A1

公开(公告)日：2021-07-08

申请号：US17144355

申请日：2021-01-08

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Lars Østergaard Pedersen ,  Justus Claus Alfred Daechsel ,  Ayodeji Abdur-rasheed Asuni ,  Nina Helen Rosenqvist ,  Christiane Volbracht ,  Lone Helboe ,  Anders Brandt ,  Florence Sotty ,  Søren Christensen ,  Jeffrey B. Stavenhagen

IPC: C07K16/18 ,  A61K39/395 ,  G01N33/68 ,  A61K49/00

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.