公开(公告)号：US20200030319A1

公开(公告)日：2020-01-30

申请号：US16291865

申请日：2019-03-04

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/08 ,  A61K47/40

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US10258617B2

公开(公告)日：2019-04-16

申请号：US15890006

申请日：2018-02-06

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/08 ,  A61K47/40

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US09913839B2

公开(公告)日：2018-03-13

申请号：US15703572

申请日：2017-09-13

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/497 ,  A61K31/495 ,  A61K9/08 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US09211288B2

公开(公告)日：2015-12-15

申请号：US14649087

申请日：2013-12-12

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo

IPC: A61K31/495 ,  A61K31/445

CPC classification number: A61K31/445 ,  A61K31/495 ,  A61K2300/00

Abstract: Pharmaceutical compositions comprising vortioxetine and donepezil are provided and the use of such composition for the treatment of cognitive dysfunctions.

Abstract translation: 提供了包含伏品酮和多奈哌齐的药物组合物，并且使用这种组合物来治疗认知功能障碍。

公开(公告)号：US20180153881A1

公开(公告)日：2018-06-07

申请号：US15890006

申请日：2018-02-06

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/495 ,  A61K9/08 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US20150297585A1

公开(公告)日：2015-10-22

申请号：US14649087

申请日：2013-12-12

Applicant: H. LUNDBECK A/S

Inventor： Connie Sanchez Morillo

IPC: A61K31/495 ,  A61K31/445

CPC classification number: A61K31/445 ,  A61K31/495 ,  A61K2300/00

Abstract: Pharmaceutical compositions comprising vortioxetine and donepezil are provided and the use of such composition for the treatment of cognitive dysfunctions.

Abstract translation: 提供了包含伏品酮和多奈哌齐的药物组合物，并且使用这种组合物来治疗认知功能障碍。

公开(公告)号：US10376506B2

公开(公告)日：2019-08-13

申请号：US15105701

申请日：2014-12-18

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Gennady N. Smagin

IPC: A61K31/4965 ,  A61K31/44 ,  A61K31/495 ,  A61K31/485

Abstract: The present invention relates to an opioid antagonist with κ-activity for use in treatment of depressive disorder with melancholic features. The invention further relates to the combination of an opioid antagonist with κ-activity and vortioxetine for use in treatment of depressive disorder with melancholic features. The invention also relates to pharmaceutical compositions comprising an opioid antagonist with κ-activity and vortioxetine.

公开(公告)号：US20180000815A1

公开(公告)日：2018-01-04

申请号：US15703572

申请日：2017-09-13

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US09820984B1

公开(公告)日：2017-11-21

申请号：US15636238

申请日：2017-06-28

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/497 ,  A61K31/495 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US20160310488A1

公开(公告)日：2016-10-27

申请号：US15105701

申请日：2014-12-18

Applicant: H. LUNDBECK A/S

Inventor： Connie Sanchez Morillo ,  Gennady N. Smagin

IPC: A61K31/495 ,  A61K31/485

CPC classification number: A61K31/495 ,  A61K31/485 ,  A61K2300/00

Abstract: The present invention relates to an opioid antagonist with κ-activity for use in treatment of depressive disorder with melancholic features. The invention further relates to the combination of an opioid antagonist with κ-activity and vortioxetine for use in treatment of depressive disorder with melancholic features. The invention also relates to pharmaceutical compositions comprising an opioid antagonist with κ-activity and vortioxetine.

Abstract translation: 本发明涉及具有κ-活性的阿片类拮抗剂，其用于治疗具有忧郁症特征的抑郁障碍。 本发明还涉及阿片类拮抗剂与κ-活性的组合以及用于治疗抑郁障碍与忧郁症特征的维生素B的组合。 本发明还涉及包含具有κ-活性的阿片样物质拮抗剂和伏妥他汀的药物组合物。