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![SOLID FORMS OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2024/06/13/US20240190909A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240190909A1
公开(公告)日：2024-06-13
申请号：US18511231
申请日：2023-11-16
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez De Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
CPC classification number: C07H15/26 , C07B2200/13
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.-
![Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2024/01/02/US11858954B2/abs.jpg.150x150.jpg)
公开(公告)号：US11858954B2
公开(公告)日：2024-01-02
申请号：US17392970
申请日：2021-08-03
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
CPC classification number: C07H15/26 , C07B2200/13
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.-
![SOLID FORMS OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID](/abs-image/US/2022/01/27/US20220024962A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220024962A1
公开(公告)日：2022-01-27
申请号：US17392970
申请日：2021-08-03
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fogh Jacobsen
IPC: C07H15/26
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
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![Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid](/abs-image/US/2021/09/28/US11130775B2/abs.jpg.150x150.jpg)
公开(公告)号：US11130775B2
公开(公告)日：2021-09-28
申请号：US16876908
申请日：2020-05-18
Applicant: H. Lundbeck A/S
Inventor： Klaus Gjervig Jensen , Lisbet Kværnø , Morten Jørgensen , Martin Juhl , Heidi Lopez de Diego , Karin Fredholt , Frans Dennis Therkelsen , Tobias Gylling Frihed , Mikkel Fog Jacobsen
IPC: C07H15/26
Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
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