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公开(公告)号:US08236352B2
公开(公告)日:2012-08-07
申请号:US10701064
申请日:2003-11-05
申请人: H. William Bosch , Niels P. Ryde , Rajeev A. Jain , Jon Swanson , Robert Hontz , John G. Devane , Kenneth Ian Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
发明人: H. William Bosch , Niels P. Ryde , Rajeev A. Jain , Jon Swanson , Robert Hontz , John G. Devane , Kenneth Ian Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
CPC分类号: A61K9/1623 , A61K9/0056 , A61K9/146 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2081
摘要: The present invention is directed to nanoparticulate compositions comprising glipizide. The glipizide particles of the composition preferably have an effective average particle size of less than about 2 microns.
摘要翻译: 本发明涉及包含格列吡嗪的纳米颗粒组合物。 组合物的格列吡嗪颗粒优选具有小于约2微米的有效平均粒度。
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公开(公告)号:US20130011447A1
公开(公告)日:2013-01-10
申请号:US13620570
申请日:2012-09-14
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
CPC分类号: A61K9/146 , A61K9/2054 , A61K9/2077
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US20090297619A1
公开(公告)日:2009-12-03
申请号:US12483188
申请日:2009-06-11
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary G. Liversidge
IPC分类号: A61K9/14 , A61P37/02 , A61K31/55 , A61K31/5513 , A61K31/5517 , A61K31/53 , A61K31/519 , A61K31/135 , A61K31/437 , A61K31/4164 , A61K38/13 , A61K31/52 , A61K31/573
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2054
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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4.
公开(公告)号:US20080248123A1
公开(公告)日:2008-10-09
申请号:US12078027
申请日:2008-03-26
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
IPC分类号: A61K9/14 , A61K31/551 , A61K31/5513 , A61K31/53 , A61K31/519 , A61K31/135 , A61K31/44 , A61K31/415 , A61K38/13 , A61K31/56 , A61K31/52 , A61P25/08 , A61P37/06
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2054
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US20110300210A1
公开(公告)日:2011-12-08
申请号:US13102795
申请日:2011-05-06
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
IPC分类号: A61K9/14 , A61K9/48 , A61K9/28 , A61K9/20 , A61K31/551
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2054
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US20080124393A1
公开(公告)日:2008-05-29
申请号:US11979231
申请日:2007-10-31
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2054
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US08293277B2
公开(公告)日:2012-10-23
申请号:US09337675
申请日:1999-06-22
申请人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
发明人: Jon Swanson , Rajeev A. Jain , Robert Hontz , John G. Devane , Kenneth Iain Cumming , Maurice Joseph Anthony Clancy , Janet Elizabeth Codd , Gary Liversidge
CPC分类号: A61K9/146 , A61K9/2054 , A61K9/2077
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US6165506A
公开(公告)日:2000-12-26
申请号:US148332
申请日:1998-09-04
申请人: Rajeev A. Jain , Linden Wei , Jon Swanson
发明人: Rajeev A. Jain , Linden Wei , Jon Swanson
IPC分类号: A61K9/51 , A61K9/14 , A61K9/20 , A61K9/46 , A61K31/192 , A61K47/04 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/34 , A61P25/04 , A61P29/00 , A01N37/10 , A61L9/04
CPC分类号: A61K9/2077 , A61K9/0007 , A61K9/146 , A61K9/2009
摘要: Described are solid dose nanoparticulate naproxen formulations having high rates of dissolution. The solid dose nanoparticulate naproxen formulations can comprise an alkali compound, which functions to increase the dissolution rate of the naproxen following administration. Alternatively, the solid dose nanoparticulate naproxen formulation can comprise an alkali compound and an acidic compound, which can react together to form carbon dioxide. The formed carbon dioxide can also aid in increasing the dissolution rate of the naproxen following administration. Also described are solid dose nanoparticulate naproxen formulations having a decreased concentration of a binder/disintegrant agent. Such compositions also provide an increased rate of dissolution of naproxen following administration.
摘要翻译: 描述了具有高溶解速率的固体剂量纳米颗粒萘普生制剂。 固体剂量纳米颗粒萘普生制剂可以包含碱性化合物,其用于在施用后增加萘普生的溶出速率。 或者,固体剂量纳米颗粒萘普生制剂可以包含可以一起反应形成二氧化碳的碱性化合物和酸性化合物。 形成的二氧化碳还可以有助于在施用后增加萘普生的溶解速率。 还描述了具有降低的粘合剂/崩解剂的浓度的固体剂量纳米颗粒萘普生制剂。 这样的组合物还提供萘普生在给药后的溶出速率增加。
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9.
公开(公告)号:US20070048378A1
公开(公告)日:2007-03-01
申请号:US11592264
申请日:2006-11-03
申请人: Jon Swanson , Rajeev Jain , Robert Hontz , John Devane , Kenneth Cumming , Maurice Joseph Clancy , Janet Codd
发明人: Jon Swanson , Rajeev Jain , Robert Hontz , John Devane , Kenneth Cumming , Maurice Joseph Clancy , Janet Codd
IPC分类号: A61K9/26
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2054
摘要: Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer.
摘要翻译: 描述了包含要施用的纳米颗粒剂的控释纳米颗粒制剂和用于在施用后延长试剂释放的速率控制聚合物。 该新型组合物在施用后释放约2至约24小时或更长时间的时间。
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公开(公告)号:US20050232151A1
公开(公告)日:2005-10-20
申请号:US10993268
申请日:2004-11-19
申请人: Adam Chapweske , Jon Swanson
发明人: Adam Chapweske , Jon Swanson
CPC分类号: H04L1/0018 , H04L1/0002 , H04L1/0014 , Y02D50/10
摘要: A method for controlling real time data communications over a packet based network comprises steps of dynamically measuring data packet loss between a receiver and a sender on the network, dynamically measuring data latency between the sender and receiver, and comparing the dynamically measured data packet loss to a loss limit and comparing the dynamically measured data latency to a latency limit. If one or both of the loss limit or the latency limit is exceeded, then the method may include reducing the rate of data transmission from the sender.
摘要翻译: 一种用于控制基于分组的网络上的实时数据通信的方法包括以下步骤:动态测量网络上的接收机和发送者之间的数据分组丢失,动态测量发送方和接收方之间的数据等待时间,并将动态测量的数据分组丢失与 损失限制,并将动态测量的数据延迟与延迟限制进行比较。 如果超过损失限制或延迟限制中的一个或两个,则该方法可以包括降低从发送者的数据传输速率。
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