公开(公告)号：US10456479B2

公开(公告)日：2019-10-29

申请号：US15558917

申请日：2015-03-19

申请人： HANGZHOU DAC BIOTECH CO., LTD.

发明人： Sanxing Sun ,  Robert Yongxin Zhao ,  Xing Li ,  Huihui Guo ,  Junxiang Jia ,  Hongsheng Xie ,  Xiaomai Zhou ,  Yuanyuan Huang ,  Qingliang Yang ,  Xiaotao Zhuo ,  Hangbo Ye ,  Shun Gai ,  Lan Qu ,  Wenjun Li ,  Chen Lin

IPC分类号： A61K47/68 ,  C07D207/46 ,  C07F9/6558 ,  C07K16/00 ,  C07K16/28

摘要： Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.

公开(公告)号：US10646585B2

公开(公告)日：2020-05-12

申请号：US16226093

申请日：2018-12-19

申请人： HANGZHOU DAC BIOTECH CO., LTD.

发明人： Sanxing Sun ,  Robert Yongxin Zhao ,  Xing Li ,  Huihui Guo ,  Junxiang Jia ,  Hongsheng Xie ,  Xiaomai Zhou ,  Yuanyuan Huang ,  Qingliang Yang ,  Xiaotao Zhuo ,  Hangbo Ye ,  Shun Gai ,  Lan Qu ,  Wenjun Li ,  Chen Lin

IPC分类号： A61K47/68 ,  C07F9/572 ,  C07K16/28 ,  C07K16/00 ,  C07F9/6558 ,  C07D207/46 ,  C07K16/32 ,  A61K39/00

摘要： Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.