公开(公告)号：US20240216493A1

公开(公告)日：2024-07-04

申请号：US18607029

申请日：2024-03-15

申请人： HDT Bio Corp

发明人： Steven Gregory Reed ,  Darrick Albert Carter ,  Malcolm Scott Duthie ,  Lars Peter Aksel Berglund ,  Jesse Hong-Sae Erasmus ,  Jiho Kim

IPC分类号： A61K39/00 ,  A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  C12N15/86

CPC分类号： A61K39/001193 ,  A61K9/4858 ,  A61K9/5015 ,  A61K9/5115 ,  A61K9/5123 ,  A61K39/001156 ,  A61K39/001186 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6075 ,  C12N2720/12143

摘要： The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. Nucleic acids provided herein include those encoding for cancer antigens (full length proteins or fragments) as well as antibodies. Methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.