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公开(公告)号：US20210353606A1
公开(公告)日：2021-11-18
申请号：US17257804
申请日：2019-07-03
发明人： Ahmed S.A. Ahmed , Martin Empting , Mostafa Hamed , Rolf W. Hartmann , Jörg Haupenthal , Thomas Hesterkamp , Ahmed A.M. Kamal , Christine K. Maurer , Teresa Röhrig , Christian Schütz , Samir Yahiaoui , Michael Zender
IPC分类号： A61K31/4439 , C07D401/12 , C07D401/14 , C07D471/04 , C07D403/12 , C07D417/12 , C07D417/14 , C07D413/12 , C07D405/14 , A61P31/04 , A61K31/444 , A61K31/506 , A61K45/06
摘要： The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
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公开(公告)号：US11883387B2
公开(公告)日：2024-01-30
申请号：US17257804
申请日：2019-07-03
发明人： Ahmed S. A. Ahmed , Martin Empting , Mostafa Hamed , Rolf W. Hartmann , Jörg Haupenthal , Thomas Hesterkamp , Ahmed A. M. Kamal , Christine K. Maurer , Teresa Röhrig , Christian Schütz , Samir Yahiaoui , Michael Zender
IPC分类号： A61K31/4439 , A61P31/04 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , A61P31/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
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