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公开(公告)号:US20180194788A1
公开(公告)日:2018-07-12
申请号:US15874325
申请日:2018-01-18
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: C07F9/6509 , C07D401/04 , C07D213/89 , C07D213/74 , A61K45/06 , A61K31/44 , A61K31/56 , A61K31/496 , A61K31/473 , A61K31/675
CPC分类号: C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号:US10717721B2
公开(公告)日:2020-07-21
申请号:US16228835
申请日:2018-12-21
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: C07D213/74 , C07D401/04 , A61K31/496 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675 , C07F9/6509 , A61P25/22 , A61P13/10 , A61P25/24 , A61P1/08 , A61K9/00 , A61K31/573
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号:US12071421B2
公开(公告)日:2024-08-27
申请号:US17699522
申请日:2022-03-21
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: C07D401/04 , A61K9/00 , A61K31/4178 , A61K31/439 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/573 , A61K31/675 , A61K45/06 , A61P1/08 , A61P13/10 , A61P25/22 , A61P25/24 , C07D213/74 , C07D213/76 , C07D213/89 , C07F9/02 , C07F9/6509
CPC分类号: C07D401/04 , A61K9/0019 , A61K31/4178 , A61K31/439 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/573 , A61K31/675 , A61K45/06 , A61P1/08 , A61P13/10 , A61P25/22 , A61P25/24 , C07D213/74 , C07D213/76 , C07D213/89 , C07F9/025 , C07F9/650952
摘要: Disclosed are compounds including phosphate and N-oxide prodrugs of the NK1 antagonist netupitant, useful in the prevention and/or treatment of diseases including emesis induced by chemotherapy. Also disclosed are methods of making a di-tert-butyl (chloromethyl) phosphate useful in the manufacture of such prodrugs by reacting a dialkylphosphate salt with an acid to obtain the corresponding ester of phosphoric acid, reacting the ester with a quaternary ammonium hydroxide base to form a monobasic salt, and reacting the monobasic salt with chloroiodomethane to form the corresponding chloromethyl dialkyl phosphate.
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公开(公告)号:US20150011510A1
公开(公告)日:2015-01-08
申请号:US14360991
申请日:2012-11-28
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Guiliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: C07D213/89 , A61K31/675 , A61K45/06 , A61K31/496 , C07D213/76 , C07F9/06 , C07D213/72
CPC分类号: C07D213/89 , C07D213/72 , C07D213/74 , C07D213/76 , C07D401/04 , C07F9/062
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译: 公开了用于预防和/或治疗由神经激肽(NK1)受体病理生理介导的疾病的化合物,组合物和方法。 该化合物具有通式(I):
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公开(公告)号:US20220401463A1
公开(公告)日:2022-12-22
申请号:US17699522
申请日:2022-03-21
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: A61K31/675 , C07F9/6509 , C07D213/76 , A61K31/496 , A61K31/4178 , A61K31/439 , C07F9/02
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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公开(公告)号:US11312698B2
公开(公告)日:2022-04-26
申请号:US16896135
申请日:2020-06-08
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: A61K31/4427 , A61K31/496 , C07D213/74 , C07D401/04 , A61K31/56 , A61K45/06 , C07D213/89 , A61K31/44 , A61K31/473 , A61K31/675 , C07F9/6509 , A61P25/22 , A61P13/10 , A61P25/24 , A61P1/08 , A61K9/00 , A61K31/573
摘要: Fosnetupitant chloride hydrochloride having improved stability, characterized by the following chemical structure:
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公开(公告)号:US20190177296A1
公开(公告)日:2019-06-13
申请号:US16228835
申请日:2018-12-21
发明人: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号: C07D401/04 , A61K9/00 , A61K31/496 , A61K31/573 , A61K31/473 , A61P1/08 , A61P13/10 , A61P25/24 , A61P25/22
摘要: Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
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