公开(公告)号：US20150080589A1

公开(公告)日：2015-03-19

申请号：US14325869

申请日：2014-07-08

申请人： Hetero Research Foundation

发明人： Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Rapolu RAJI REDDY ,  Bandi VAMSI KRISHNA ,  Kesireddy SUBASH CHANDER REDDY

IPC分类号： C07D493/04

CPC分类号： C07D493/04 ,  C07D307/93

摘要： The present invention provides novel crystalline hydrochloride salt of darunavir, process for its preparation and to pharmaceutical composition comprising it. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it.

摘要翻译： 本发明提供了地瑞那韦的新型结晶盐酸盐，其制备方法和包含其的药物组合物。 本发明还提供了地瑞那韦无定形形式的新方法和包含它的药物组合物。

公开(公告)号：US20140235859A1

公开(公告)日：2014-08-21

申请号：US14264450

申请日：2014-04-29

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi PARTHASARADHI REDDY ,  Kura RATHNAKAR REDDY ,  Rapolu RAJI REDDY ,  Dasari MURALIDHARA REDDY ,  Bandi VAMSI KRISHNA ,  Voggu RAMESH REDDY

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07D401/14

摘要： The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL.

摘要翻译： 本发明涉及奥美拉唑的分辨方法。 本发明还提供了奥美拉唑环胺盐的新型对映体化合物及其制备方法。 本发明还提供（R） - 或（S） - 奥美拉唑环胺盐的固体及其制备方法。 本发明还提供了制备基本上不含其三水合物形式的艾美拉唑镁二水合物的方法。 本发明还提供了制备手性BINOL回收的方法。