公开(公告)号：US20220117934A1

公开(公告)日：2022-04-21

申请号：US17428699

申请日：2020-01-23

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takao KUROKAWA ,  Hiroyuki ARAKI ,  Kimiko KOMATANI

IPC: A61K31/381 ,  A61K9/70 ,  A61K47/32 ,  A61K47/06

Abstract: The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.