公开(公告)号：US20210267882A1

公开(公告)日：2021-09-02

申请号：US17253311

申请日：2019-06-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61M37/00 ,  A61K47/36 ,  A61K31/4174

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：US20190350840A1

公开(公告)日：2019-11-21

申请号：US16473119

申请日：2017-12-25

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Toshihiro KOGURE ,  Seiji TOKUMOTO ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K31/135 ,  A61M37/00 ,  A61K47/20 ,  A61K47/02

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

公开(公告)号：US20220409524A1

公开(公告)日：2022-12-29

申请号：US17902303

申请日：2022-09-02

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Toshihiro KOGURE ,  Seiji TOKUMOTO ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K31/135 ,  A61K47/20 ,  A61K47/02 ,  A61M37/00

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

公开(公告)号：US20250152502A1

公开(公告)日：2025-05-15

申请号：US19021981

申请日：2025-01-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K47/36 ,  A61M37/00

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.