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    Applicator
    2.
    发明申请
    Applicator 审中-公开
    申请人

    公开(公告)号：US20160263363A1

    公开(公告)日：2016-09-15

    申请号：US15032709

    申请日：2014-11-04

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke ARAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

    Abstract translation: 施用器被构造成通过皮肤用皮肤穿刺用微针将活性成分转移到皮肤中。 涂抹器包括活塞板，活塞板在活塞板的主体的下表面侧设置有第一突出部和第二突出部。 微针设置在第一突出部的表面上。 第二突起部分设置在与第一突出部分间隔开的第一突出部分的周边。

    Microneedle Device and Method for Producing the Same
    3.
    发明申请
    Microneedle Device and Method for Producing the Same 有权

    公开(公告)号：US20250152502A1

    公开(公告)日：2025-05-15

    申请号：US19021981

    申请日：2025-01-15

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Ryota HORI ,  Shinpei NISHIMURA

    IPC: A61K9/00 ,  A61K31/4174 ,  A61K47/36 ,  A61M37/00

    Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

    MICRONEEDLE DEVICE AND METHOD FOR PRODUCING SAME
    4.
    发明申请
    MICRONEEDLE DEVICE AND METHOD FOR PRODUCING SAME 有权

    公开(公告)号：US20230045891A1

    公开(公告)日：2023-02-16

    申请号：US17788019

    申请日：2020-12-18

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Tatsuya SHIMIZU ,  Takako ESU ,  Shinpei NISHIMURA

    IPC: A61M37/00 ,  A61L31/08 ,  A61L31/16 ,  A61K31/4174 ,  A61K9/00 ,  A61K31/137 ,  A61K47/18 ,  A61K47/36

    Abstract: The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

    Microneedle Device and Method for Producing the Same
    6.
    发明申请
    Microneedle Device and Method for Producing the Same 有权

    公开(公告)号：US20210267882A1

    公开(公告)日：2021-09-02

    申请号：US17253311

    申请日：2019-06-20

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Ryota HORI ,  Shinpei NISHIMURA

    IPC: A61K9/00 ,  A61M37/00 ,  A61K47/36 ,  A61K31/4174

    Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

    Applicator
    8.
    发明申请
    Applicator 审中-公开

    公开(公告)号：US20190083770A1

    公开(公告)日：2019-03-21

    申请号：US15756234

    申请日：2016-08-19

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Masafumi ONO

    IPC: A61M37/00

    Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

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