公开(公告)号：US20230045891A1

公开(公告)日：2023-02-16

申请号：US17788019

申请日：2020-12-18

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tatsuya SHIMIZU ,  Takako ESU ,  Shinpei NISHIMURA

IPC: A61M37/00 ,  A61L31/08 ,  A61L31/16 ,  A61K31/4174 ,  A61K9/00 ,  A61K31/137 ,  A61K47/18 ,  A61K47/36

Abstract: The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.