公开(公告)号：US12186287B2

公开(公告)日：2025-01-07

申请号：US18083793

申请日：2022-12-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Yusuke Tanaka ,  Keiichiro Tsurushima

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass % to 6 mass % with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to a total mass of the adhesive layer.

公开(公告)号：US11166921B2

公开(公告)日：2021-11-09

申请号：US16963537

申请日：2019-01-23

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yusuke Tanaka ,  Masahiro Sato ,  Kentaro Nakashima ,  Takaaki Yoshinaga

IPC: A61K9/70 ,  A61K31/045 ,  A61K31/05 ,  A61K31/125 ,  A61K31/618 ,  A61K36/534

Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.