公开(公告)号：US12186287B2

公开(公告)日：2025-01-07

申请号：US18083793

申请日：2022-12-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Yusuke Tanaka ,  Keiichiro Tsurushima

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass % to 6 mass % with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to a total mass of the adhesive layer.

公开(公告)号：US11166921B2

公开(公告)日：2021-11-09

申请号：US16963537

申请日：2019-01-23

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yusuke Tanaka ,  Masahiro Sato ,  Kentaro Nakashima ,  Takaaki Yoshinaga

IPC: A61K9/70 ,  A61K31/045 ,  A61K31/05 ,  A61K31/125 ,  A61K31/618 ,  A61K36/534

Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.

公开(公告)号：US12297380B2

公开(公告)日：2025-05-13

申请号：US17798412

申请日：2021-02-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Kento Ichinohe ,  Keiichiro Tsurushima ,  Takaaki Yoshinaga

IPC: C09J133/02 ,  C09J7/30 ,  C09J11/06 ,  C09J11/08

Abstract: A method for producing an adhesive layer composition for producing a cooling sheet including a backing layer, an adhesive layer, and a liner layer, the method comprising the step of: mixing a composition to be mixed containing water, an alum, sodium edetate, a polyacrylic acid, and a neutralized polyacrylic acid such that a mixing temperature becomes 5 to 23° C., to obtain an adhesive layer composition, wherein in the composition to be mixed, a content of the water is 69 to 938.24% by mass relative to a total mass of the composition to be mixed, a content of the alum is 0.18 to 0.42% by mass relative to the total mass of the composition to be mixed, a content of the sodium edetate is 0.08 to 0.18% by mass relative to the total mass of the composition to be mixed, and a mass ratio between the content of the alum and the content of the sodium edetate (the content of the alum: the content of the sodium edetate) is 1:1 to 5.25:1.

公开(公告)号：US10292941B2

公开(公告)日：2019-05-21

申请号：US15547645

申请日：2016-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Masahiro Sato ,  Yasuhisa Kose ,  Takaaki Yoshinaga

IPC: A61K9/70 ,  B32B5/02 ,  A61F13/00 ,  A61F13/02 ,  A61K47/06 ,  A61K47/34 ,  B32B27/00 ,  A61K31/045 ,  A61K31/618

Abstract: Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric, the adhesive agent layer comprises an SIS block copolymer and liquid paraffin, the adhesive patch has a first direction, which is a predetermined reference axis direction, and a second direction, which is orthogonal to the first direction, and a bending resistance in the first direction of the adhesive patch is 18 to 30 mm.