公开(公告)号：US3906034A

公开(公告)日：1975-09-16

申请号：US34155973

申请日：1973-03-15

Applicant: HOECHST AG

Inventor： FRANZ RAIMUND ,  DUWEL DIETER

IPC: A23K1/16 ,  A61K31/60 ,  C07C67/00 ,  C07C201/16 ,  C07C205/60 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/65 ,  C07C233/66 ,  C07C235/64 ,  C07C103/76

CPC classification number: C07C205/60

Abstract: Anthelminthically active salicylanilides of the formula

IN WHICH X1 and X2 each represent hydrogen, chlorine, methyl or trifluoromethyl, Y1 and Y2 each represent hydrogen, chlorine or the nitrogroup, at least one of the substituents Y1 and Y2 not being hydrogen, and Z stands for -OH, -O-CO-alkyl or

are described as well as their preparation by reacting a correspondingly substituted salicylic acid chloride or salicylic acid phenyl ester with an aniline derivative carrying the appropriate substituents or by nitrating a corresponding salicylanilide. The salicylanilides of the above formula are used as active ingredients in pharmaceutical preparations having anthelmintic activity.

Abstract translation: 式I的抗真菌活性水杨酰胺，其中X1和X2各自表示氢，氯，甲基或三氟甲基，Y1和Y2各自表示氢，氯或硝基，取代基Y1和Y2中的至少一个不是氢，Z代表 -OH，-O-CO-烷基或-O-H 3 N + - ，并且通过使相应取代的水杨酸氯化物或水杨酸苯酯与携带适当取代基的苯胺衍生物或 通过硝化相应的水杨酰苯胺。 在具有驱虫活性的药物制剂中使用上式的水杨酰胺作为活性成分。