公开(公告)号：US3884897A

公开(公告)日：1975-05-20

申请号：US41031273

申请日：1973-10-29

Applicant: HOECHST AG

Inventor： GEIGER ROLF ,  WISSMANN HANS ,  LANGNER DIETRICH

IPC: C07K14/575 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07C271/22 ,  C07K1/113 ,  C07K14/62 ,  C07C103/52 ,  C08H1/00

CPC classification number: C07K14/62 ,  C07C271/22 ,  Y02P20/55 ,  Y10S930/26

Abstract: BRIDGE BY Edman degradation. Compounds of the formula II.
A method for making insulin and certain derivatives thereof from a compound of the formula(I)

wherein Ac is an N-protective group removable by proton solvolysis X is hydrogen or an S-protective group, and n is 2 or 3, which comprises solvolyzing the Ac groups and dehydrogenating the -SX groups to S-S bonds to form a compound of the formula (II)
and then eliminating the

Abstract translation: 由式（I）的化合物制备胰岛素及其某些衍生物的方法，其中Ac是通过质子溶解分解可除去的N-保护基，X是氢或S-保护基，n是2或3，其包括溶剂分解 Ac基团并将-SX基团脱氢成SS键以形成式（II）的化合物，然后除去BRIDGE BY Edman降解。 式II的化合物。