公开(公告)号：US20170014789A1

公开(公告)日：2017-01-19

申请号：US15280433

申请日：2016-09-29

申请人： HOVIONE INTERNATIONAL LTD

发明人： José Luis SANTOS ,  Luis OLIVAL ,  Maria PALHA ,  Filipa MAlA ,  Filipe NEVES

IPC分类号： B01J2/04

CPC分类号： B01J2/04 ,  A61K9/1682 ,  B01D1/18

摘要： This present invention provides a spray dryer for use in preparing particles for inhalation, the spray dryer comprising a multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders and with a drying gas flow rate greater than about 80 kg/h. Also provided is a method for scaling-up a spray drying process for preparing particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer, relative in size to each other, the method comprising the use in the larger scale spray dryer of a multi-nozzle apparatus comprising single nozzles suitable for use in preparing inhalation powders, wherein the number of nozzles in the larger spray dryer is determined by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller scale spray dryer. Also provided is a multi-nozzle apparatus produced from the method of the present invention, the multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders. Also provided is the use of multiple single nozzles suitable for use in preparing inhalation powders in a spray dryer with a drying gas flow rate greater than about 80 kg/h. The nozzles used in the present invention preferably prepare particles with a mean particle size less than about 5 microns.

摘要翻译： 本发明提供了一种用于制备用于吸入的颗粒的喷雾干燥器，该喷雾干燥器包括多喷嘴装置，该多喷嘴装置包括适用于制备吸入粉末和干燥气体流速大于约80kg / h的多个单一喷嘴。 还提供了一种用于放大喷雾干燥方法的方法，该方法包括在较大规模的喷雾干燥器中使用较大规模的喷雾干燥器中的较小规模的喷雾干燥器， 一种多喷嘴装置，包括适合用于制备吸入粉末的单个喷嘴，其中较大喷雾干燥器中的喷嘴数量由较大规模喷雾干燥器的干燥气体流量与干燥气体流速的比率确定 较小规模的喷雾干燥器。 还提供了由本发明的方法制造的多喷嘴装置，该多喷嘴装置包括适合用于制备吸入粉末的多个单个喷嘴。 还提供了适用于在干燥气体流速大于约80kg / h的喷雾干燥器中制备吸入粉末的多个单个喷嘴的使用。 本发明中使用的喷嘴优选制备平均粒度小于约5微米的颗粒。