公开(公告)号：US11998861B2

公开(公告)日：2024-06-04

申请号：US17945129

申请日：2022-09-15

申请人： Velico Medical, Inc.

发明人： Robert R. Andrews ,  Herman E. Snyder ,  William J. Merritt ,  Kyle D. Erickson ,  Evan P. Ordway ,  Clair Strohl ,  Russell Barron

IPC分类号： B01D1/18 ,  F26B3/12

CPC分类号： B01D1/18 ,  F26B3/12

摘要： The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.

公开(公告)号：US20240123368A1

公开(公告)日：2024-04-18

申请号：US18097822

申请日：2023-01-17

申请人： Velico Medical, Inc.

发明人： Robert R. Andrews ,  Herman E. Snyder ,  William J. Merritt ,  Evan P. Ordway ,  Clair Strohl ,  Qiyong Peter Liu ,  Jihae Sohn

IPC分类号： A61K35/16 ,  B01D1/18

CPC分类号： A61K35/16 ,  B01D1/18

摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

公开(公告)号：US20240109000A1

公开(公告)日：2024-04-04

申请号：US17945125

申请日：2022-09-15

申请人： Velico Medical, Inc.

发明人： Qiyong Peter Liu ,  Herman E. Snyder ,  Kyle D. Erickson ,  Evan P. Ordway ,  William J. Merritt ,  Richard Meehan ,  Robert R. Andrews ,  Clair Strohl ,  Jihae Sohn

IPC分类号： B01D1/18 ,  A61K35/16 ,  B01D1/00 ,  B01J2/04

CPC分类号： B01D1/18 ,  A61K35/16 ,  B01D1/0082 ,  B01J2/04

摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

公开(公告)号：US11832629B2

公开(公告)日：2023-12-05

申请号：US16945304

申请日：2020-07-31

申请人： Leprino Foods Company

发明人： Neill Burt ,  Mark Cramer ,  Jiancai Li ,  Richard Merrill

IPC分类号： B01D1/18 ,  A23C1/04 ,  A23C1/12 ,  A23C1/14 ,  A23C9/18 ,  A23C1/01 ,  B01D1/24 ,  B01D1/14 ,  B01D1/22 ,  A23C9/16

CPC分类号： A23C1/12 ,  A23C1/01 ,  A23C1/04 ,  A23C9/16 ,  A23C9/18 ,  B01D1/14 ,  B01D1/222 ,  B01D1/24 ,  B01D1/18

摘要： Methods of making a powdered milk product are described. The methods may include providing an aqueous milk-sourced mixture, and evaporating water from the aqueous milk-sourced mixture to produce an evaporated milk-sourced mixture having a total solids concentration of 35 wt. % or more. The evaporated milk-sourced mixture may be dried to form the powdered milk product, which may have less than 6 wt. % water. Systems for making the milk powdered product are also described. The systems may include an evaporator to evaporate water from a supply of a milk-sourced mixture to form an evaporated milk-sourced mixture. They may also include a dryer to dry the evaporated milk-sourced mixture and atomize it into the powdered milk product.

公开(公告)号：US20190203367A1

公开(公告)日：2019-07-04

申请号：US16298811

申请日：2019-03-11

申请人： Westlake Vinyl Corporation

发明人： Anthony B. Davis

IPC分类号： C25B15/08 ,  B01D1/18 ,  C25B1/34 ,  B01D1/26 ,  B01D21/26

CPC分类号： C25B15/08 ,  B01D1/18 ,  B01D1/26 ,  B01D21/262 ,  B01D21/267 ,  C25B1/34

摘要： A system and method for removing impurities to reconstitute a NaCl stream to a saturated solution salt solution and remove any impurities such as sodium bisulfite (NaHSO3), sodium chlorate (NaClO3) and sodium iodide (NaI) to improve brine quality from an electrolytic cell is disclosed, including an evaporation system connected to the electrolytic cell, a brine treatment system connected to the evaporation system and the electrolytic cell. A waste treatment system is connected to the evaporation system. The evaporation system includes a set of evaporators that concentrates the brine. Sodium chloride is precipitated from the set of evaporators to the brine treatment system. Impurities are precipitated from the set of evaporators. The brine treatment system includes a hydrocyclone and a centrifuge that separates sodium chloride from water. The sodium chloride is mixed with water to create a concentrated and purified brine.

公开(公告)号：US20180306509A1

公开(公告)日：2018-10-25

申请号：US16020364

申请日：2018-06-27

申请人： MITSUBISHI HEAVY INDUSTRIES, LTD.

发明人： Toshihiro Fukuda ,  Seiji Kagawa ,  Jun Satou

IPC分类号： F26B25/00 ,  F23J15/02 ,  B01D1/18 ,  F23J15/00 ,  B01D53/34 ,  B01D53/50 ,  C02F103/18 ,  B01D53/75 ,  B01D53/64 ,  B01D53/86

CPC分类号： F26B25/009 ,  B01D1/18 ,  B01D53/343 ,  B01D53/504 ,  B01D53/505 ,  B01D53/64 ,  B01D53/75 ,  B01D53/8625 ,  B01D2251/2062 ,  B01D2251/2067 ,  B01D2251/404 ,  B01D2251/604 ,  B01D2257/2045 ,  B01D2257/302 ,  B01D2257/404 ,  B01D2257/602 ,  B01D2258/0283 ,  C02F2103/18 ,  F23J15/006 ,  F23J15/022

摘要： A method of spray drying and washing using a spray drying apparatus, includes: spraying dehydrated filtrate from a spray nozzle hung down from a top side of the spray drying apparatus; introducing a part of flue gas into the spray drying apparatus to dry the dehydrated filtrate; wherein a compressed air is introduced into the spray nozzle to facilitate the spraying and into the wash nozzle to perform air purging during the spray drying, and jetting washing liquid from a wash nozzle provided on a side wall of the spray drying apparatus to wash the spray nozzle and an inside of the spray drying apparatus body, wherein the feeding of the dehydrated filtrate to the spray nozzle is stopped during the washing.

公开(公告)号：US20180001334A1

公开(公告)日：2018-01-04

申请号：US15540454

申请日：2015-12-22

申请人： Nestec S.A.

发明人： Peter ERDMANN ,  Peter FRANKHAUSER ,  Martin NYDEGGER ,  Dale Richard SANDERS ,  Christian SCHMIED ,  Michael STRANZINGER

IPC分类号： B05B12/08 ,  B05B1/34 ,  A23L3/46 ,  A23P10/40 ,  B01J2/04 ,  F26B3/12 ,  B05B1/30

CPC分类号： B05B12/085 ,  A23C1/04 ,  A23L3/46 ,  A23P10/40 ,  A23V2002/00 ,  B01D1/18 ,  B01J2/04 ,  B05B1/3013 ,  B05B1/3447 ,  F26B3/12 ,  G01N11/00

摘要： A method of controlling the spray droplet size of a spray nozzle apparatus, in particular for the manufacturing of food powders, delivered to the spray nozzle comprises the following steps: a) providing a paste of a product to be sprayed by a spray nozzle; b) continuously determining the shear viscosity (η) of the product paste delivered to the spray nozzle; c) determining the mass flow rate (Qm) of the product paste delivered to the spray nozzle; d) determining the static pressure (P) of the product paste delivered to the spray nozzle; e) determining the density (p) of the product paste delivered to the spray nozzle; f) delivering the data obtained in steps b) to e) to a control device comprising a computer and a memory; g) calculating control data for adjusting the spray nozzle on the basis of the data obtained in steps b) to e) and on nozzle geometry parameters stored in the memory; h) sending the control data as control signals to a control means of the spray nozzle and adjusting the spray nozzle accordingly.

公开(公告)号：US20170014789A1

公开(公告)日：2017-01-19

申请号：US15280433

申请日：2016-09-29

申请人： HOVIONE INTERNATIONAL LTD

发明人： José Luis SANTOS ,  Luis OLIVAL ,  Maria PALHA ,  Filipa MAlA ,  Filipe NEVES

IPC分类号： B01J2/04

CPC分类号： B01J2/04 ,  A61K9/1682 ,  B01D1/18

摘要： This present invention provides a spray dryer for use in preparing particles for inhalation, the spray dryer comprising a multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders and with a drying gas flow rate greater than about 80 kg/h. Also provided is a method for scaling-up a spray drying process for preparing particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer, relative in size to each other, the method comprising the use in the larger scale spray dryer of a multi-nozzle apparatus comprising single nozzles suitable for use in preparing inhalation powders, wherein the number of nozzles in the larger spray dryer is determined by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller scale spray dryer. Also provided is a multi-nozzle apparatus produced from the method of the present invention, the multi-nozzle apparatus comprising multiple single nozzles suitable for use in preparing inhalation powders. Also provided is the use of multiple single nozzles suitable for use in preparing inhalation powders in a spray dryer with a drying gas flow rate greater than about 80 kg/h. The nozzles used in the present invention preferably prepare particles with a mean particle size less than about 5 microns.

摘要翻译： 本发明提供了一种用于制备用于吸入的颗粒的喷雾干燥器，该喷雾干燥器包括多喷嘴装置，该多喷嘴装置包括适用于制备吸入粉末和干燥气体流速大于约80kg / h的多个单一喷嘴。 还提供了一种用于放大喷雾干燥方法的方法，该方法包括在较大规模的喷雾干燥器中使用较大规模的喷雾干燥器中的较小规模的喷雾干燥器， 一种多喷嘴装置，包括适合用于制备吸入粉末的单个喷嘴，其中较大喷雾干燥器中的喷嘴数量由较大规模喷雾干燥器的干燥气体流量与干燥气体流速的比率确定 较小规模的喷雾干燥器。 还提供了由本发明的方法制造的多喷嘴装置，该多喷嘴装置包括适合用于制备吸入粉末的多个单个喷嘴。 还提供了适用于在干燥气体流速大于约80kg / h的喷雾干燥器中制备吸入粉末的多个单个喷嘴的使用。 本发明中使用的喷嘴优选制备平均粒度小于约5微米的颗粒。

公开(公告)号：US20160367936A1

公开(公告)日：2016-12-22

申请号：US14780896

申请日：2015-02-19

申请人： MITSUBIDHI HEAVY INDUSTRIES, LTD.

发明人： Nobuyuki Ukai ,  Hiroshi Nakashoji ,  Hideo Suzuki ,  Shigeru Yoshioka ,  Masayuki Eda ,  Susumu Okino ,  Tetsu Ushiku

IPC分类号： B01D53/73 ,  C02F1/68 ,  C02F1/58 ,  C02F5/08 ,  B01D53/64 ,  C02F9/00 ,  C02F1/52 ,  C02F1/44 ,  C02F1/12 ,  B01D1/20 ,  C02F1/42 ,  B01D53/50 ,  B01D53/80

CPC分类号： B01D53/73 ,  B01D1/18 ,  B01D1/20 ,  B01D53/501 ,  B01D53/502 ,  B01D53/64 ,  B01D53/77 ,  B01D53/80 ,  B01D2251/404 ,  B01D2251/606 ,  B01D2252/103 ,  B01D2257/302 ,  B01D2257/404 ,  B01D2257/602 ,  B01D2258/0283 ,  C01F11/464 ,  C02F1/12 ,  C02F1/16 ,  C02F1/38 ,  C02F1/42 ,  C02F1/44 ,  C02F1/444 ,  C02F1/5281 ,  C02F1/58 ,  C02F1/66 ,  C02F1/683 ,  C02F5/08 ,  C02F9/00 ,  C02F11/12 ,  C02F2001/007 ,  C02F2001/5218 ,  C02F2101/101 ,  C02F2101/20 ,  C02F2103/18 ,  C02F2209/04 ,  Y02A20/128 ,  Y02A20/131

摘要： The water treatment system includes: a wet desulfurization device that removes sulfur oxide present in boiler flue gas; a dewatering device that separates gypsum from desulfurization waste water containing gypsum slurry; a reaction tank to which separated water from the dewatering device is introduced, and which immobilizes heavy metals present in the separated water by inputting a chelating agent; a solid-liquid separation unit that performs solid-liquid separation with respect to heavy metal sludge present in the separated water; a mixing unit that mixes the separated water obtained with effluent generated in a plant facility; a desalination device that removes salt content from the mixed water mixed by the mixing unit; and a spray drying device that includes a spray unit, which sprays concentrated water in which the salt content has been concentrated by the desalination device, and that performs spray drying using a part of the boiler flue gas.

摘要翻译： 水处理系统包括：去除锅炉烟道中存在的硫氧化物的湿式脱硫装置; 将石膏与含有石膏浆料的脱硫废水分离的脱水装置; 导入脱水装置的分离水的反应槽，通过输入螯合剂固定存在于分离水中的重金属; 相对于存在于分离水中的重金属污泥进行固液分离的固液分离单元; 混合单元，其将得到的分离水与在工厂设备中产生的流出物混合; 脱盐装置，其从混合单元混合的混合水中除去盐分; 以及喷雾干燥装置，其包括喷雾单元，其喷射通过脱盐装置使盐含量已经浓缩的浓缩水，并且使用一部分锅炉烟道气进行喷雾干燥。

公开(公告)号：US20160353794A1

公开(公告)日：2016-12-08

申请号：US15164294

申请日：2016-05-25

申请人： Symrise AG

发明人： Alexander Balde ,  Alexander Diring ,  Eric Gruber ,  Marc Hoffmann ,  Alexander Silbernagel ,  Viktor Vorrat ,  Jenny Weißbrodt

IPC分类号： B28B1/54

CPC分类号： B01D1/18 ,  A23L27/70 ,  A23P10/22 ,  A23P10/40 ,  A23V2002/00 ,  B01J2/04

摘要： The invention is in the field of devices for producing particles, in particular large agglomerate particles.

摘要翻译： 本发明在用于生产颗粒，特别是大的附聚颗粒的装置领域中。