公开(公告)号：US20200338135A1

公开(公告)日：2020-10-29

申请号：US16958962

申请日：2018-12-27

申请人： HYOGO COLLEGE OF MEDICINE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

发明人： Tomohiro MATSUYAMA ,  Takayuki NAKAGOMI ,  Yu FUKUDA

IPC分类号： A61K35/36 ,  G01N33/50 ,  G01N33/15

摘要： A lipocalin-type prostaglandin D2 synthase (L-PGDS) production promoting agent, more specifically an L-PGDS production promoting agent in pericytes or ischemia-induced multipotent stem cells (iSCs) dedifferentiated from pericytes. A substance having an L-PGDS production promoting action is contained in an extract from inflamed tissues inoculated with vaccinia virus. An L-PGDS production promoting agent is highly useful as a prophylactic, therapeutic or relapse prophylactic agent for a disease in which the effect by promotion of L-PGDS expression is expected to be effective, including a cerebrovascular disorder such as cerebral infarction, dementia such as Alzheimer's disease, or a sleep disorder.

公开(公告)号：US20240000853A1

公开(公告)日：2024-01-04

申请号：US18355925

申请日：2023-07-20

申请人： HYOGO COLLEGE OF MEDICINE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

发明人： Tomohiro MATSUYAMA ,  Takayuki NAKAGOMI ,  Yu FUKUDA

IPC分类号： A61K35/36 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K35/36 ,  G01N33/15 ,  G01N33/50 ,  A61K9/0053

摘要： A lipocalin-type prostaglandin D2 synthase (L-PGDS) production promoting agent, more specifically an L-PGDS production promoting agent in pericytes or ischemia-induced multipotent stem cells (iSCs) dedifferentiated from pericytes. A substance having an L-PGDS production promoting action is contained in an extract from inflamed tissues inoculated with vaccinia virus. An L-PGDS production promoting agent is highly useful as a prophylactic, therapeutic or relapse prophylactic agent for a disease in which the effect by promotion of L-PGDS expression is expected to be effective, including a cerebrovascular disorder such as cerebral infarction, dementia such as Alzheimer's disease, or a sleep disorder.