公开(公告)号：US20220154278A1

公开(公告)日：2022-05-19

申请号：US17527807

申请日：2021-11-16

Applicant: HYSENSBIO ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Joo Cheol PARK ,  Dong Seol LEE ,  Geumbit HWANG

IPC: C12Q1/6883 ,  A61K38/17

Abstract: CPNE7 protein or a nucleotide encoding for CPNE7 protein, or compositions containing the CPNE7 or the nucleotide and their uses are disclosed. The protein, nucleotide, or composition is useful for preventing or treating fatty liver disease. The CPEN7 protein regulates the expression of the SREBF1 (SREBP1) gene or a gene encoding the same. The composition can be a pharmaceutical composition or a quasi-drug composition, a health functional food, or a dietary supplement, which is suitable for preventing or alleviating fatty liver disease.

公开(公告)号：US20230257419A1

公开(公告)日：2023-08-17

申请号：US18009236

申请日：2021-06-01

Applicant: HYSENSBIO

Inventor： Joo Hwang PARK ,  Ji Hyun LEE ,  Dong Seol LEE

IPC: C07K7/06 ,  A61P1/02 ,  A61K9/00

CPC classification number: C07K7/06 ,  A61P1/02 ,  A61K9/0056

Abstract: The present invention provides a pharmaceutical composition for preventing or treating periodontal disease or a dislocated traumatic tooth, comprising a peptide of a specific amino acid sequence and a composition for regenerating periodontium.

公开(公告)号：US20230310278A1

公开(公告)日：2023-10-05

申请号：US18023497

申请日：2021-09-03

Applicant: HYSENSBIO

Inventor： Joo Hwang PARK ,  Dong Seol LEE

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/2055 ,  A61J1/2041 ,  A61J1/201

Abstract: A drug mixing unit for a syringe is disclosed. The drug mixing unit contains a barrel member having a first flow path through which a liquid drug is to be pushed in; and a plug member having an insertion part inserted into the barrel member, the insertion part having a second flow path, for drawing out a drug mixture, formed on inner side thereof and a through hole, connected to the second flow path, formed on one surface thereof, wherein the plug member is connected to the barrel member to form a predetermined drug mixing space, the drug mixing space has a drug to be mixed with the liquid drug that has been pushed in through the first flow path. The unit also contain a third flow path, through which the drug mixture flows from the drug mixing space to the through hole.

公开(公告)号：US20210052699A1

公开(公告)日：2021-02-25

申请号：US16958512

申请日：2018-12-17

Applicant: HYSENSBIO ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Joo Hwang PARK ,  Ji Hyun LEE ,  Joo Cheol PARK ,  Dong Seol LEE

IPC: A61K38/17 ,  A23L33/18 ,  A61P1/02

Abstract: Provided are compositions including a CPNE4 protein or a polynucleotide encoding thereof, a pharmaceutical composition, a quasi-drug composition, a dietary supplement, and a health functional food composition. A method for preventing or treating dentin-dental disease or periodontal disease and a method and a method for promoting regeneration of hard tissue including dentin, bone and cementum, and/or pulp tissue are disclosed.