公开(公告)号：US20190023664A1

公开(公告)日：2019-01-24

申请号：US16069546

申请日：2017-01-12

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Eyal Yosef MISHANI ,  Ofer SHAMNI ,  Galith Rachel ABOURBEH-GOFRIT

IPC: C07D239/94 ,  C07B59/00 ,  A61K51/04 ,  C12Q1/6886 ,  A61P35/00 ,  A61K45/06

CPC classification number: C07D239/94 ,  A61K45/06 ,  A61K51/0459 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C12Q1/6886 ,  C12Q2600/106

Abstract: Radiolabeled compounds which are erlotinib analogs that feature a radioactive halogen and processes of preparing same are disclosed. Uses of these radiolabeled compounds in radioimaging, for identifying and monitoring a level, distribution and/or mutational status of deregulated EGFR, and/or in radiotherapy, are also disclosed.