公开(公告)号：US11865090B2

公开(公告)日：2024-01-09

申请号：US16977722

申请日：2019-03-06

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Eithan Galun ,  Hilla Giladi ,  Chofit Chai ,  Nofar Rosenberg ,  Dayana Yaish ,  Zohar Shmuelian

IPC: C07H21/02 ,  A61K31/167 ,  A61P35/04 ,  A61P35/00

CPC classification number: A61K31/167 ,  A61P35/00 ,  A61P35/04

Abstract: The present invention provides compositions having one or more agents capable of increasing expression of one or more endogenous tumor suppressive mi RNAs in one or more producing cells, such that the endogenous mi RNAs can affect one or more target cancer cells. Further provided are method and uses thereof for treating cancer.

公开(公告)号：US10392617B2

公开(公告)日：2019-08-27

申请号：US15109879

申请日：2015-01-06

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Hilla Giladi ,  Alina Simerzin ,  Yael Hantz ,  Sagit Arbel Alon ,  Eithan Galun

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K45/06 ,  A61K31/713 ,  A61K31/7088

Abstract: The present invention provides miR-122* as a functional microRNA molecule, compositions comprising the same and uses thereof for treatment of various conditions, such as, cancer. Further provided are methods for increasing the expression, stability and/or activity of p53 in a target cell or method for inducing cancer cell death, the methods comprising introducing into the cell a miR-122* polynucleotide molecule or a vector expressing or encoding the same.