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    N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
    1.
    发明授权
    N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics 失效
    N-己酰基至正十七烷酰基-5-羟基色氨酸-5-羟基色氨酰胺，用作止痛剂

    公开(公告)号：US4482567A

    公开(公告)日：1984-11-13

    申请号：US433283

    申请日：1982-10-07

    申请人： Hadassah Tamir ,  Stephen E. Karpiak ,  Meir Wilchek

    发明人： Hadassah Tamir ,  Stephen E. Karpiak ,  Meir Wilchek

    IPC分类号： A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K38/00 ,  A61P25/04 ,  C07D209/20 ,  C07K5/06 ,  C07K5/078 ,  C07D401/12

    CPC分类号： C07K5/06156 ,  C07D209/20

    摘要： Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C.sub.2 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.16 alkenyl, C.sub.2 -C.sub.16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;R.sup.1 and R.sup.1a are each H or methyl;R.sup.2 and R.sup.2a are each H or R, as defined above;R.sup.3 and R.sup.3a are each H or alkyl containing from 1 to 4 carbons;R.sup.4 and R.sup.4a are each H or alkyl containing from 1 to 4 carbons;and their non-toxic, pharmacologically acceptable acid addition salts.

    摘要翻译： 镇痛作用的5-羟色氨酸衍生物公开于下列通式：其中R选自C 2 -C 16烷基，C 3 -C 8环烷基，C 2 -C 16烯基，C 2 -C 16炔基 ，含有至多14个碳原子的芳基和含有至多20个碳原子的芳基烷基; R1和R1a各自为H或甲基; R2和R2a各自为H或R，如上所定义; R3和R3a各自为H或含有1至4个碳的烷基; R4和R4a各自为H或含有1至4个碳的烷基; 及其无毒，药理学上可接受的酸加成盐。

    N-acylated 5-hydroxytryptophan amide derivatives
    2.
    发明授权
    N-acylated 5-hydroxytryptophan amide derivatives 失效
    N-酰化的5-羟基色氨酸酰胺衍生物

    公开(公告)号：US4658038A

    公开(公告)日：1987-04-14

    申请号：US671109

    申请日：1984-11-13

    申请人： Hadassah Tamir ,  Stephen E. Karpiak ,  Meir Wilchek

    发明人： Hadassah Tamir ,  Stephen E. Karpiak ,  Meir Wilchek

    IPC分类号： C07D209/20 ,  C07K5/078

    CPC分类号： C07K5/06156 ,  C07D209/20

    摘要： Analgesia-effecting 5-hydroxytryptophan derivatives are disclosed of the formulae: ##STR1## wherein R is selected from the group consisting of C.sub.2 -C.sub.16 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.16 alkenyl, C.sub.2 -C.sub.16 alkynyl, aryl containing up to 14 carbon atoms, and arylalkyl containing up to 20 carbon atoms;R.sup.2 and R.sup.2a are each H or R, as defined above;R.sup.3 and R.sup.3a are each H or alkyl containing from 1 to 4 carbons;R.sup.4 and R.sup.4a are each H or alkyl containing from 1 to 4 carbons;and their non-toxic, pharmacologically acceptable acid addition salts.

    摘要翻译： 镇痛作用的5-羟色氨酸衍生物公开于下列通式：其中R选自C 2 -C 16烷基，C 3 -C 8环烷基，C 2 -C 16烯基，C 2 -C 16炔基 ，含有至多14个碳原子的芳基和含有至多20个碳原子的芳基烷基; R2和R2a各自为H或R，如上所定义; R3和R3a各自为H或含有1至4个碳的烷基; R4和R4a各自为H或含有1至4个碳的烷基; 及其无毒，药理学上可接受的酸加成盐。