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1.发明申请公开(公告)号：US20100136007A1
公开(公告)日：2010-06-03
申请号：US12626598
申请日：2009-11-25
Applicant: Haishan LIN , Li Long
Inventor： Haishan LIN , Li Long
CPC classification number: C07K14/7153 , A61K38/00 , C07K2319/30
Abstract: The present invention relates to specific CSF1R ECD fusion molecules that exhibit improved therapeutic properties. The invention also relates to polypeptide and polynucleotide sequences, vectors, host cells, and compositions comprising or encoding such molecules. The invention also relates to methods of making and using the CSF1R ECD fusion molecules. The invention further relates to methods of treatment using the CSF1R ECD fusion molecules. For example, certain CSF1R ECDs of the invention may be used to treat rheumatoid arthritis (RA) or multiple sclerosis (MS).
Abstract translation: 本发明涉及具有改善的治疗性质的特异性CSF1R ECD融合分子。 本发明还涉及包含或编码这种分子的多肽和多核苷酸序列，载体，宿主细胞和组合物。 本发明还涉及制备和使用CSF1R ECD融合分子的方法。 本发明还涉及使用CSF1R ECD融合分子的治疗方法。 例如，本发明的某些CSF1R ECD可用于治疗类风湿性关节炎（RA）或多发性硬化症（MS）。
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2.发明申请TREATMENT OF OSTEOLYTIC DISORDERS AND CANCER USING CSF1R EXTRACELLULAR DOMAIN FUSION MOLECULES 有权使用CSF1R细胞域融合分子治疗骨质疏松症和癌症公开(公告)号：US20100136006A1
公开(公告)日：2010-06-03
申请号：US12626583
申请日：2009-11-25
Applicant: Haishan LIN , Li Long
Inventor： Haishan LIN , Li Long
IPC: A61K39/395 , A61K38/16 , A61P35/00 , A61P37/04
CPC classification number: C07K14/70567 , A61K38/1793 , A61K47/60 , A61K47/643 , C07K2319/30
Abstract: Methods of using colony stimulating factor receptor (CSF1R) extracellular domain (ECD) fusion molecules to treat treating osteolytic bone loss, cancer metastasis, cancer metastasis-induced osteolytic bone loss, and tumor growth are provided. CSF1R ECD fusion molecules, polynucleotides encoding CSF1R ECD fusion molecules, and methods of making CSF1R ECD fusion molecules are also provided.
Abstract translation: 提供了使用集落刺激因子受体（CSF1R）细胞外结构域（ECD）融合分子治疗溶骨性骨丢失，癌症转移，癌转移诱导的溶骨性骨丢失和肿瘤生长的方法。 还提供了CSF1R ECD融合分子，编码CSF1R ECD融合分子的多核苷酸，以及制备CSF1R ECD融合分子的方法。
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