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    PEPTIDES
    1.
    发明申请
    PEPTIDES 审中-公开

    公开(公告)号：US20180346546A1

    公开(公告)日：2018-12-06

    申请号：US15777885

    申请日：2016-11-23

    申请人： IMMUNOCORE LIMITED ,  ADAPTIMMUNE LIMITED

    发明人： Alex POWLESLAND ,  Meidai SUN

    IPC分类号： C07K14/74 ,  C07K7/06 ,  C07K14/725

    CPC分类号： C07K14/70567 ,  A61K38/00 ,  C07K7/06 ,  G01N2333/70539

    摘要： The present invention relates to novel peptides derived from Nuclear receptor subfamily 0 group B member 1 (NR0B1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.

    Novel Substitution Mutant Receptors and Their Use in an Ecdysone Receptor-Based Inducible Gene Expression System
    3.
    发明申请
    Novel Substitution Mutant Receptors and Their Use in an Ecdysone Receptor-Based Inducible Gene Expression System 审中-公开
    新型替代突变体受体及其在蜕皮激素受体诱导型基因表达系统中的应用

    公开(公告)号：US20170015728A1

    公开(公告)日：2017-01-19

    申请号：US14972901

    申请日：2015-12-17

    申请人： Intrexon Corporation

    发明人： Subba Reddy PALLI ,  Marianna Zinovievna Kapitskaya

    IPC分类号： C07K14/705 ,  C12N15/63

    CPC分类号： C07K14/70567 ,  C07K14/721 ,  C12N15/63

    摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel nuclear receptors comprising a substitution mutation and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene within a host cell using this inducible gene expression system.

    摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及包含取代突变的新型核受体及其在基于核受体的诱导型基因表达系统中的用途以及使用该诱导型基因表达系统调节宿主细胞内基因表达的方法。

    Host cells and methods using a repressor polypeptide and an inducible promoter for gene expression
    5.
    发明申请
    Host cells and methods using a repressor polypeptide and an inducible promoter for gene expression 审中-公开
    宿主细胞和使用抑制子多肽和诱导型启动子进行基因表达的方法

    公开(公告)号：US20170002363A1

    公开(公告)日：2017-01-05

    申请号：US15201248

    申请日：2016-07-01

    申请人： The Regents of the University of California

    发明人： Thomas L. Ruegg

    IPC分类号： C12N15/63 ,  C07K14/245

    CPC分类号： C07K14/245 ,  C07K14/70567 ,  C12N15/63

    摘要： The present invention provides for a system comprising (a) a first nucleic acid comprising a nucleotide sequence encoding a nucleotide sequence of interest operatively linked to a promoter comprising a repressor polypeptide binding site, and (b) a second nucleic acid comprising a nucleotide sequence encoding a repressor polypeptide having at least 70% amino acid identity with EilR, SmvR, KmrR, RcdA, or QacR; wherein expression of the nucleotide sequence of interest from the promoter is induced by the presence of a hydrophobic inducer, such as a hydrophobic cation inducer, such as a triarylmethane, acridine, phenazine, phenothiazine, or xanthene.

    摘要翻译： 本发明提供了一种系统，其包含（a）第一核酸，其包含编码与包含阻遏物多肽结合位点的启动子可操作地连接的目的核苷酸序列的核苷酸序列，和（b）第二核酸，其包含编码 与EilR，SmvR，KmrR，RcdA或QacR具有至少70％氨基酸同一性的阻遏物多肽; 通过存在疏水性诱导剂，例如疏水性阳离子诱导剂，例如三芳基甲烷，吖啶，吩嗪，吩噻嗪或呫吨，可以诱导来自启动子的目标核苷酸序列的表达。

    Steroidal Ligands and Their Use in Gene Switch Modulation
    8.
    发明申请
    Steroidal Ligands and Their Use in Gene Switch Modulation 有权
    甾体配体及其在基因开关调制中的应用

    公开(公告)号：US20140057349A1

    公开(公告)日：2014-02-27

    申请号：US13947631

    申请日：2013-07-22

    申请人： Intrexon Corporation

    发明人： Robert E. HORMANN ,  Silvia Lapenna ,  Laurence Neil Dinan

    IPC分类号： C12N15/85

    CPC分类号： C12N15/85 ,  A61K31/575 ,  C07C49/727 ,  C07C49/753 ,  C07J9/00 ,  C07K14/70567 ,  C07K2319/715 ,  C12N2830/002

    摘要： The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear receptor complexes and one or more steroidal ligands. Further aspects include ligand compositions including therapeutic compositions.

    摘要翻译： 本发明涉及用于基于核受体的诱导型基因表达系统的甾体配体。 本发明还涉及用含有一种或多种核受体复合物和一种或多种甾体配体的系统调节感兴趣的基因表达的方法。 其它方面包括包括治疗组合物的配体组合物。