公开(公告)号：US20230115871A1

公开(公告)日：2023-04-13

申请号：US17622360

申请日：2019-06-24

申请人： Hangzhou DAC Biotech Co., Ltd

发明人： Robert Yongxin ZHAO ,  Qingliang YANG ,  Linyao ZHAO ,  Yuanyuan HUANG ,  Hangbo YE ,  Shun GAI ,  Junxiang JIA ,  Lu BAI ,  Wenjun LI ,  Zhixiang GUO ,  Chen LIN ,  Jun ZHENG ,  Huihui GUO ,  Minjun CAO ,  Xiangfei KONG ,  Yong DU ,  Yifang XU ,  Xiaomai ZHOU ,  Hongsheng XIE ,  Xiuzhen ZHANG ,  Miaomiao CHEN ,  Xiaolei LIU ,  Xiang CAI ,  Binbin CHEN ,  Yanlei YANG ,  Lingli ZHANG

IPC分类号： A61K47/68

摘要： The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

公开(公告)号：US20230241241A1

公开(公告)日：2023-08-03

申请号：US18001899

申请日：2020-06-19

申请人： HANGZHOU DAC BIOTECH CO., LTD.

发明人： Robert ZHAO ,  Qingliang YANG ,  Hangbo YE ,  Yuanyuan HUANG ,  Yifang XU ,  Gengxiang ZHAO ,  Diancheng CHEN ,  Huihui GUO ,  Xiangfei KONG ,  Wenjun LI ,  Lu BAI ,  Xiang CAI ,  Xiuzhen ZHANG ,  Junxiang JIA ,  Zhixiang GUO ,  Shangma HUANG ,  Xiaoxu WANG ,  Jun ZHENG ,  Yong DU ,  Yanhua LI ,  Yunxia ZHENG ,  Chen LIN ,  Xiaoxiao CHEN ,  Wei ZHENG ,  Xinyan JIANG ,  Lingli ZHANG ,  Riping YE ,  Miaomiao CHEN

IPC分类号： A61K47/68 ,  A61P35/00

CPC分类号： A61K47/6849 ,  A61K47/6803 ,  A61P35/00 ,  A61K47/6851

摘要： This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

公开(公告)号：US20220249594A1

公开(公告)日：2022-08-11

申请号：US17596956

申请日：2020-02-18

申请人： HANGZHOU DAC BIOTECH CO., LTD

发明人： Robert ZHAO ,  Qingliang YANG ,  Yuanyuan HUANG ,  Shun GAI ,  Hangbo YE ,  Linyao ZHAO ,  Huihui GUO ,  Lu BAI ,  Wenjun LI ,  Junxiang JIA ,  Zhixiang GUO ,  Jun ZHENG ,  Xiaoxiao CHEN ,  Xiangfei KONG ,  Chen LIN ,  Yong DU ,  Yu ZHANG ,  Lei ZHOU ,  Xiuzhen ZHANG ,  Xiuhong ZHENG ,  Binbin CHEN ,  Yanlei YANG ,  Meng DAI ,  Yifang XU ,  Zhongliang FAN ,  Xiaomai ZHOU ,  Xingyan JIANG ,  Miaomiao CHEN ,  Lingli ZHANG ,  Yanhua LI

IPC分类号： A61K38/08 ,  A61K9/19 ,  A61K47/54 ,  A61K47/64 ,  A61K47/65 ,  A61K47/55 ,  A61K51/08

摘要： A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, ----, R1, R2, R3, R4, R1, R6, R7, R1, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.