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公开(公告)号：US20230098334A1
公开(公告)日：2023-03-30
申请号：US17681991
申请日：2022-02-28
发明人： Feifei Wu , Zhongyi Chen , Wanjun Jiang , Jie Li , Shitu Ma , Mengjun Hu
IPC分类号： C08B37/08
摘要： The invention discloses a thiolated chitosan and a preparation method thereof, which is chitosan co-modified by hydroxybutyl and sulfhydryl. The preparation method includes the following steps: firstly, hydroxybutyl is introduced into a chitosan molecular chain, and then sulfhydryl is introduced as a sulfhydryl moiety by a condensation reaction between free amino of hydroxybutyl chitosan and carboxyl of L-cysteine. An aqueous solution of the thiolated chitosan of the invention is in a solution state at low temperature, and can be flow-injected. When the temperature rises to around 37° C., a hydrogel can be formed. Due to the introduction of sulfhydryl, the antioxidant ability and tissue adhesion ability of the material are increased. The thiolated chitosan prepared according to the method may have wide application prospects in an aspect such as tissue engineering, drug delivery systems, cell culture, cosmetics, etc.
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公开(公告)号：US20220296781A1
公开(公告)日：2022-09-22
申请号：US17335039
申请日：2021-05-31
发明人： Qiang Zhang , Mengjun Hu , Feifei Wu , Wei Huang , Weiqing Sun
摘要： The present application provides an injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells, and a preparation method and application thereof. The present application includes: preparing hydroxypropyl chitin from chitin through modification, preparing a composite with collagen and sodium hyaluronic, constructing the injectable temperature-sensitive composite hydrogel, loading adipose-derived mesenchymal stem cells of New Zealand rabbit and Genipin, and finally forming in-situ the injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells at the physiological temperature. The hydrogel prepared in the present application is of a three-dimensional porous structure, which is conducive to transferring of nutrients and metabolic waste, so as to provide an excellent microenvironment for the growth of cells, helping maintain survival rate and biological activity of the adipose-derived mesenchymal stem cells, and promoting differentiation of the adipose-derived mesenchymal stem cells into cartilage tissue, while having high mechanical strength, and thus can be widely used in cartilage tissue engineering.
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