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公开(公告)号：USRE44338E1
公开(公告)日：2013-07-02
申请号：US13550853
申请日：2012-07-17
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang , Virginia M. Y. Lee , John Q. Trojanowski , Daniel M. Skovronsky
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang , Virginia M. Y. Lee , John Q. Trojanowski , Daniel M. Skovronsky
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2208
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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公开(公告)号：USRE44354E1
公开(公告)日：2013-07-09
申请号：US13550885
申请日：2012-07-17
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang , Virginia M. Y. Lee , John Q. Trojanowski , Daniel M. Skovronsky
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang , Virginia M. Y. Lee , John Q. Trojanowski , Daniel M. Skovronsky
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2208
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form-amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及成像淀粉样沉积物和标记化合物的方法，以及制备用于成像淀粉样沉积物的标记化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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公开(公告)号：US07858072B2
公开(公告)日：2010-12-28
申请号：US11305350
申请日：2005-12-19
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： A61K49/00
CPC分类号： A61K51/04
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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公开(公告)号：US06696039B2
公开(公告)日：2004-02-24
申请号：US10127678
申请日：2002-04-23
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： A61M3614
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2208
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及成像淀粉样沉积物和标记化合物的方法，以及制备用于成像淀粉样沉积物的标记化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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公开(公告)号：US08465726B2
公开(公告)日：2013-06-18
申请号：US12765397
申请日：2010-04-22
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
CPC分类号： A61K51/04 , C07B59/001 , C07C217/80
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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公开(公告)号：US07759502B2
公开(公告)日：2010-07-20
申请号：US11926319
申请日：2007-10-29
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： C07D307/34
CPC分类号： C07C323/25 , A61K51/0478 , C07B2200/05 , C07C211/52 , C07C323/34 , C07C323/60 , C07D213/38 , C07D307/56 , C07D307/66 , C07D311/16 , C07D333/28
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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公开(公告)号：US07425318B2
公开(公告)日：2008-09-16
申请号：US11203429
申请日：2005-08-15
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： A61K49/00
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2208
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及成像淀粉样沉积物和标记化合物的方法，以及制备用于成像淀粉样沉积物的标记化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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公开(公告)号：US07297820B2
公开(公告)日：2007-11-20
申请号：US11218587
申请日：2005-09-06
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： C07C211/00 , A61K31/135
CPC分类号： C07C323/25 , A61K51/0478 , C07B2200/05 , C07C211/52 , C07C323/34 , C07C323/60 , C07D213/38 , C07D307/56 , C07D307/66 , C07D311/16 , C07D333/28
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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9.发明授权Stilbene derivatives and their use for binding and imaging amyloid plaques 失效二苯乙烯衍生物及其用于结合和成像淀粉样蛋白斑的用途公开(公告)号：US07250525B2
公开(公告)日：2007-07-31
申请号：US10228275
申请日：2002-08-27
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： C07C211/45 , A61M36/14 , A61K31/135 , C07C211/20 , A61K31/00
CPC分类号： C07C323/25 , A61K51/0478 , C07B2200/05 , C07C211/52 , C07C323/34 , C07C323/60 , C07D213/38 , C07D307/56 , C07D307/66 , C07D311/16 , C07D333/28
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及成像淀粉样沉积物和标记化合物的方法，以及制备用于成像淀粉样沉积物的标记化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集以形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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公开(公告)号：US06946116B2
公开(公告)日：2005-09-20
申请号：US10739217
申请日：2003-12-19
申请人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
发明人： Hank F. Kung , Mei-Ping Kung , Zhi-Ping Zhuang
IPC分类号： C07D487/04 , A61K31/437 , A61K31/5025 , A61K51/00 , A61K51/04 , A61P25/28 , A61P43/00 , C07D471/04 , C07F7/22 , C07F13/00 , A61M36/14
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2208
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form-amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
摘要翻译： 本发明涉及成像淀粉样沉积物和标记化合物的方法，以及制备用于成像淀粉样沉积物的标记化合物的方法。 本发明还涉及化合物和制备用于抑制淀粉样蛋白聚集形成淀粉样沉积物的化合物的方法，以及将治疗剂递送至淀粉样沉积物的方法。
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