公开(公告)号：US20240293584A1

公开(公告)日：2024-09-05

申请号：US18585905

申请日：2024-02-23

申请人： The Johns Hopkins University

发明人： Xing Yang ,  Sridhar Nimmagadda ,  Steven Rowe ,  Stephanie Slania ,  Martin G. Pomper

IPC分类号： A61K51/04 ,  A61K47/54

CPC分类号： A61K51/0485 ,  A61K47/545 ,  A61K51/0478 ,  A61K51/0482

摘要： Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.

公开(公告)号：US11938201B2

公开(公告)日：2024-03-26

申请号：US18354282

申请日：2023-07-18

申请人： The Johns Hopkins University

发明人： Xing Yang ,  Sridhar Nimmagadda ,  Steven Rowe ,  Stephanie Slania ,  Martin G. Pomper

IPC分类号： A61K51/00 ,  A61K47/54 ,  A61K51/04 ,  A61M36/14

CPC分类号： A61K51/0485 ,  A61K47/545 ,  A61K51/0478 ,  A61K51/0482

摘要： Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.

公开(公告)号：US11865195B2

公开(公告)日：2024-01-09

申请号：US16881182

申请日：2020-05-22

申请人： Lantheus Medical Imaging, Inc. ,  Yale University

发明人： Albert J. Sinusas ,  Joseph G. Akar ,  Richard R. Cesati ,  Heike S. Radeke ,  Stephen B. Haber

IPC分类号： A61K51/04 ,  A61K51/08

CPC分类号： A61K51/044 ,  A61K51/0459 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/0497 ,  A61K51/08 ,  A61B2576/023

摘要： The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.

公开(公告)号：US11833229B2

公开(公告)日：2023-12-05

申请号：US17745100

申请日：2022-05-16

申请人： SCV—SpezialChemikalienVertrieb GmbH

发明人： Frank Rösch ,  Lukas Greifenstein ,  Nils Engelbogen ,  Ralf Bergmann

IPC分类号： A61K51/04 ,  A61K47/54

CPC分类号： A61K51/0497 ,  A61K47/54 ,  A61K51/0478 ,  A61K51/0482

摘要： The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111In, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.

公开(公告)号：US11813339B2

公开(公告)日：2023-11-14

申请号：US16484706

申请日：2018-02-06

申请人： IGL Pharma, Inc.

发明人： Jaime Simon ,  R. Keith Frank

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  A61P35/00 ,  A61P35/04 ,  A61P19/08 ,  A61P7/00 ,  G21G1/02

CPC分类号： A61K51/0482 ,  A61K51/0478 ,  A61P35/00 ,  A61P7/00 ,  A61P19/08 ,  A61P35/04 ,  G21G1/02

摘要： This invention relates to radioactive, bone-seeking, pharmaceutical compositions that are administered multiple times to a patient, have a lower impurity profile, a longer shelf life, and are less expensive to prepare.

公开(公告)号：US11795064B2

公开(公告)日：2023-10-24

申请号：US15772881

申请日：2016-11-17

申请人： TORAY INDUSTRIES, INC.

发明人： Masao Kamogawa ,  Mitsuhito Suwa ,  Hiroko Mitsui ,  Miki Nakamichi

IPC分类号： C01G25/00 ,  H05B33/22 ,  C08L85/00 ,  C08G79/00 ,  C08K3/22 ,  G02B1/11 ,  B32B9/00 ,  H05B33/28 ,  C07F7/08 ,  H10K50/00 ,  G02B5/28 ,  A61K51/04

CPC分类号： C01G25/006 ,  B32B9/00 ,  C07F7/0836 ,  C08G79/00 ,  C08K3/22 ,  C08L85/00 ,  G02B1/11 ,  G02B5/28 ,  H05B33/22 ,  H05B33/28 ,  H10K50/00 ,  A61K51/0478

摘要： Disclosed is a polymetalloxane including a constituent unit represented by the following general formula (1), which stably exists in a transparent and uniform state in a solution and can form a homogeneous cured film:




wherein R1 is an organic group and at least one of R1 is an (R33SiO—) group, R3 is optionally selected from specific groups, R2 is optionally selected from specific groups, when plural R1, R2, and R3 exist, they may be the same or different, M represents a specific metal atom, m is an integer indicating a valence of a metal atom M, and a is an integer of 1 to (m−2).

公开(公告)号：US11690923B2

公开(公告)日：2023-07-04

申请号：US17379011

申请日：2021-07-19

申请人： UNIVERSITY OF THE FREE STATE ,  UNIVERSITÄT ZÜRICH

发明人： Andreas Roodt ,  Roger Ariel Alberto ,  Angelo Frei ,  Petrus Pennie Mokolokolo ,  Robin Kim Bollinger ,  Alice Brink ,  Dumisani Vincent Kama

IPC分类号： A61K51/04

CPC分类号： A61K51/0478

摘要： Multinuclear complexes and methods for preparing them are provided. The discrete multinuclear complexes include a one or more transition metals and a radioisotope having the same coordination geometry as the transition metal. A bridging ligand is coordinated to the transition metal and the radioisotope to link the transition metal and the radioisotope and pendent ligands are coordinated to each of the transition metal and the radioisotope to stabilise the complex. The multinuclear complexes may include a radioisotope or radioelement that can be detected by medical equipment and may find use in therapy and/or the diagnosis of disease in patients.

公开(公告)号：US20190209116A1

公开(公告)日：2019-07-11

申请号：US16003006

申请日：2018-06-07

申请人： Progenics Pharmaceuticals, Inc. ,  EXINI Diagnostics AB

发明人： Karl Vilhelm Sjöstrand ,  Jens Filip Andreas Richter ,  Kerstin Elsa Maria Johnsson ,  Erik Konrad Gjertsson

IPC分类号： A61B6/00 ,  G06T15/08 ,  G06T7/00 ,  G06T5/30 ,  G06K9/46 ,  A61B6/03 ,  A61K51/04

CPC分类号： A61B6/5217 ,  A61B6/037 ,  A61B6/465 ,  A61B6/466 ,  A61B6/467 ,  A61B6/50 ,  A61B6/5223 ,  A61B6/5229 ,  A61B6/5258 ,  A61K51/0478 ,  G06F3/04842 ,  G06K9/4647 ,  G06K2209/051 ,  G06N3/04 ,  G06N3/0454 ,  G06N3/08 ,  G06T5/30 ,  G06T7/0014 ,  G06T15/08 ,  G06T2200/24 ,  G06T2207/10108 ,  G06T2207/30081 ,  G06T2207/30096

摘要： Presented herein are systems and methods that provide for automated analysis of three-dimensional (3D) medical images of a subject in order to automatically identify specific 3D volumes within the 3D images that correspond to specific organs and/or tissue. In certain embodiments, the accurate identification of one or more such volumes can be used to determine quantitative metrics that measure uptake of radiopharmaceuticals in particular organs and/or tissue regions. These uptake metrics can be used to assess disease state in a subject, determine a prognosis for a subject, and/or determine efficacy of a treatment modality.

公开(公告)号：US20190111162A1

公开(公告)日：2019-04-18

申请号：US15751299

申请日：2016-08-11

申请人： ENDOCYTE, INC.

发明人： Christopher Paul LEAMON

IPC分类号： A61K51/04

CPC分类号： A61K51/0478 ,  A61K51/0497

摘要： The present disclosure relates to a method for imaging cancer by administering to a patient a labeled chelating compound and an unlabeled chelating compound.

公开(公告)号：US20180369428A1

公开(公告)日：2018-12-27

申请号：US15564214

申请日：2016-04-06

申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Jeong Soo YOO ,  Swarbhanu SARKAR ,  Yeong Su HA ,  Woong Hee LEE

IPC分类号： A61K49/10

CPC分类号： A61K49/106 ,  A61K49/0002 ,  A61K51/0478 ,  A61K51/0482 ,  A61K51/0491 ,  A61K51/0497 ,  C07B59/004 ,  C07F1/08 ,  G01R33/5601

摘要： Provided is a probe for detecting in vivo hydrogen sulfide, specifically, a probe for detecting hydrogen sulfide including a complex compound into which a radioactive isotope Cu is introduced. According to specific embodiments of the present disclosure, as a result of real-time observing animal models, in which hydrogen sulfide involved in various diseases is generated in a large quantity, through optical and nuclear medicine imaging, the probe for detecting hydrogen sulfide according to the present disclosure may selectively bind with hydrogen sulfide to provide images of a site where hydrogen sulfide has abnormally increased in a cell or a tissue, thereby detecting a disease in an unexpected site without affecting the anatomical properties of the body. In addition, the probe for detecting hydrogen sulfide quickly reacts with hydrogen sulfide, thereby solving the existing problem of waiting a predetermined time for testing after an imaging agent is injected. Accordingly, the probe may be effectively used as a means for diagnosing diseases, such as a composition for imaging, an imaging method, etc.