公开(公告)号：US20140275870A1

公开(公告)日：2014-09-18

申请号：US13835143

申请日：2013-03-15

申请人： Hannu HARJUNMAA ,  Rebecca Burrell ,  Stevan Kun

发明人： Hannu HARJUNMAA ,  Rebecca Burrell ,  Stevan Kun

IPC分类号： A61B5/1455 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0205

CPC分类号： A61B5/1455 ,  A61B5/0004 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/1495

摘要： A method may include directing a radiation beam at a sample, the beam including two periods of radiation having different wavelengths, an analyte in a fluid within the sample having different absorption coefficients for the two different wavelengths, detecting the beam with a detector when the sample is in a first fluid state, the detector configured to generate an output signal proportional to an intensity of the beam at each of the two different wavelengths, detecting the beam with the detector when the sample is in a second fluid state, the sample transitioning from the first fluid state to the second fluid state by a pulsation of the sample, obtaining estimates of an amount of fluid at the first and second fluid states, and determining an analyte concentration estimate based on the output signal and the estimate of the amount of fluid at the first and second fluid states.

摘要翻译： 方法可以包括在样品处引导辐射束，所述束包括具有不同波长的两个辐射周期，样品内的流体中的分析物对于两个不同波长具有不同的吸收系数，当样品 处于第一流体状态，检测器被配置为产生与两个不同波长中的每一个处的波束的强度成比例的输出信号，当样品处于第二流体状态时，检测器与检测器检测波束，样品从 通过样品的脉动将第一流体状态转换到第二流体状态，获得在第一和第二流体状态下的流体量的估计，以及基于输出信号和流体量的估计来确定分析物浓度估计 在第一和第二流体状态。

公开(公告)号：US20130267798A1

公开(公告)日：2013-10-10

申请号：US13441447

申请日：2012-04-06

申请人： Hannu HARJUNMAA ,  Stevan Kun

发明人： Hannu HARJUNMAA ,  Stevan Kun

IPC分类号： A61B5/1455 ,  A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6843

摘要： A method and apparatus for noninvasively measuring the concentration of a target analyte in a sample matrix using a fiberless transflectance probe is described. It includes directing a beam of electromagnetic radiation, consisting of at least two components of different wavelengths, to the sample matrix and conducting the backscattered radiation to a detector which outputs a signal indicative of the differential absorption of the two wavelengths in the sample matrix. The transflectance probe comprises a tapered tubular housing having an inner reflective surface, an optical rod having an outer reflective surface, and a detection window which serves as an interface between the probe and the surface of the sample matrix. The method and apparatus described are particularly useful in measuring the concentration of glucose in tissue containing blood.

摘要翻译： 描述了使用无纤维透射探针来非侵入性地测量样品基质中的目标分析物的浓度的方法和装置。 它包括将由至少两个不同波长的分量组成的电磁辐射束引导到样本矩阵，并将反向散射辐射导向检测器，该检测器输出指示样本矩阵中两个波长的差分吸收的信号。 透射探针包括具有内部反射表面的锥形管状壳体，具有外部反射表面的光学棒和用作探针与样品基质表面之间的界面的检测窗口。 所述的方法和装置在测量含有血液的组织中的葡萄糖浓度时特别有用。