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公开(公告)号:US08852552B2
公开(公告)日:2014-10-07
申请号:US13885393
申请日:2011-11-15
CPC分类号: A61K51/0472 , A61K49/10 , A61K51/0421 , A61K51/086 , A61K51/088 , C07F9/65522 , C07F9/70 , C07F9/80 , G01N33/60
摘要: Provided herein are novel compounds based on xanthene, for example biarsenical compounds, which are useful as molecular probes. The compounds contain at least one isotope atom, such as a radioisotope atom. Methods for visualizing tetracysteine-tagged analyte molecules such as proteins using said compounds, methods for synthesizing said compounds, and methods for treating cancer or other hyperproliferative disorders using said compounds are also provided.
摘要翻译: 本文提供了基于呫吨的新型化合物,例如可用作分子探针的双缩醛化合物。 该化合物含有至少一个同位素原子,例如放射性同位素原子。 还提供了使用所述化合物显现四羧酸标记的分析物分子如蛋白质的方法,用于合成所述化合物的方法,以及使用所述化合物治疗癌症或其它过度增殖性疾病的方法。
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公开(公告)号:US20130323168A1
公开(公告)日:2013-12-05
申请号:US13885393
申请日:2011-11-15
CPC分类号: A61K51/0472 , A61K49/10 , A61K51/0421 , A61K51/086 , A61K51/088 , C07F9/65522 , C07F9/70 , C07F9/80 , G01N33/60
摘要: Provided herein are novel compounds based on xanthene, for example biarsenical compounds, which are useful as molecular probes. The compounds contain at least one isotope atom, such as a radioisotope atom. Methods for visualizing tetracysteine-tagged analyte molecules such as proteins using said compounds, methods for synthesizing said compounds, and methods for treating cancer or other hyperproliferative disorders using said compounds are also provided.
摘要翻译: 本文提供了基于呫吨的新型化合物,例如可用作分子探针的双缩醛化合物。 该化合物含有至少一个同位素原子,例如放射性同位素原子。 还提供了使用所述化合物显现四羧酸标记的分析物分子如蛋白质的方法,用于合成所述化合物的方法,以及使用所述化合物治疗癌症或其它过度增殖性疾病的方法。
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