Active-substance preparation for oral administration, especially to
ruminants
    4.
    发明授权
    Active-substance preparation for oral administration, especially to ruminants 失效
    用于口服给药的活性物质制剂,特别是反刍动物

    公开(公告)号:US5279832A

    公开(公告)日:1994-01-18

    申请号:US820777

    申请日:1992-01-15

    CPC分类号: A61K9/5073 A23K40/35

    摘要: A dosage form for administering physiologically active substances to animals, especially ruminant animals. The dosage unit includes a core which contains the active substance and a coating. The coating has selected areas which are thinner than the average thickness of the coating and/or areas which are predetermined rupture sites. These thin areas or predetermined rupture sites are constructed and arranged so as to detach and/or rupture under the conditions which are present after oral administration of the dosage form. As a result, the delayed release of the physiologically-active substance is accelerated. For example, the coating may be formulated to not be affected in the first stomach of a ruminant but to rapidly disintegrate in the animal's second stomach.

    摘要翻译: 2.1饲料添加剂和药物等活性成分通常以延迟方式释放,或者经口给药缓慢释放。 特别是在反刍动物的情况下,在瘤胃中应该释放很少或没有。 适当的封装是昂贵的,并且特别是对于相对大量的产品的管理而言是不合适的并且太昂贵。 这种类型的已知包封也具有可疑的生理可接受性和/或不允许的缺点。 2.2新型封装包含相对薄的区域和/或预定的断裂点,与基本上均匀的涂层相比,其加速了释放。 诸如颗粒的角度细节优选地被包封,所述包封以这样的方式形成,使得在口服给药之后胶囊可以在边缘断裂。 封装优选由两层组成,内层含有填料加成膜剂,外层仅含有成膜剂。 2.3包封适用于营养目的的活性剂的保护管理,例如甲硫氨酸,或用于医疗,特别是兽医,特别是反刍动物的治疗。