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    Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists
    1.
    发明授权
    Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists 失效
    乙内酰脲衍生物作为白细胞粘附的抑制剂和VLA-4拮抗剂

    公开(公告)号：US06514952B1

    公开(公告)日：2003-02-04

    申请号：US09405843

    申请日：1999-09-27

    申请人： Hans Ulrich Stilz ,  Volkmar Wehner ,  Christoph Huels ,  Dirk Seiffge

    发明人： Hans Ulrich Stilz ,  Volkmar Wehner ,  Christoph Huels ,  Dirk Seiffge

    IPC分类号： A61K31675

    CPC分类号： C07K5/1024 ,  C07K5/0202

    摘要： Compounds of the formula I in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I, and of pharmaceutical preparations which contain such compounds, for the treatment and prophylaxis of diseases which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell—cell or cell-matrix interactions play a part which are based on interactions of VLA-4 receptors with their ligands, for example of inflammatory processes, rheumatoid arthritis or allergic disorders, and it also relates to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases. It further relates to novel compounds of the formula I.

    摘要翻译： B，D，E，R，W，Y，Z，b，c，d，e，f，g具有权利要求中所示含义的式Iin化合物是白细胞的粘附和迁移的抑制剂， /或属于整联蛋白组的粘附受体VLA-4的拮抗剂。 本发明涉及式I化合物和含有这些化合物的药物制剂的用途，用于治疗和预防由白细胞粘附和/或白细胞迁移的不期望程度或与之相关的或与其相关的疾病 其中细胞 - 细胞或细胞 - 基质相互作用发挥基于VLA-4受体与其配体（例如炎性过程，类风湿性关节炎或过敏性疾病）的相互作用的一部分，并且还涉及使用 用于生产用于此类疾病的药物的配方Ⅰ。 它还涉及式I的新化合物。