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1.发明授权Method for screening for an anti-CD4 antibody suitable for use in immunotherapy 有权筛选适合用于免疫治疗的抗CD4抗体的方法公开(公告)号：US08685651B2
公开(公告)日：2014-04-01
申请号：US12392556
申请日：2009-02-25
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: G01N33/53
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Abstract translation: 衍生自小鼠单克隆抗CD4抗体B-F5的人源化抗体能够激活CD25 + CD4 +调节性T细胞，并且可用于制备免疫抑制组合物。
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公开(公告)号：US20090104190A1
公开(公告)日：2009-04-23
申请号：US12246660
申请日：2008-10-07
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: A61K39/395 , C07K16/44 , A61P37/06 , C07H21/00
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Abstract translation: 衍生自小鼠单克隆抗CD4抗体B-F5的人源化抗体能够激活CD25 + CD4 +调节性T细胞，并且可用于制备免疫抑制组合物。
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3.发明申请Regulatory T-Cells Containing Galectins for the Therapy and Diagnosis of Diseases 审中-公开含有凝乳酶的调节性T细胞用于治疗和诊断疾病公开(公告)号：US20080118515A1
公开(公告)日：2008-05-22
申请号：US10564588
申请日：2004-07-15
Applicant: Petra Lutter , Petra Weingarten , Christoph Huels , Hemut E. Meyer , Edgar Schmitt , Helmut Jonuleit
Inventor： Petra Lutter , Petra Weingarten , Christoph Huels , Hemut E. Meyer , Edgar Schmitt , Helmut Jonuleit
IPC: A61K39/395 , C12N5/08 , C07K16/28
CPC classification number: C12N5/0636 , A61K38/00 , A61K2035/124 , A61K2039/505 , C07K14/4726 , C07K16/18 , C12N2501/505 , C12N2501/59 , G01N33/5047 , G01N2333/4724
Abstract: The invention relates to regulator T-cells containing galectins, in particular, the use thereof as markers and for the therapy and diagnosis of diseases, in particular, of allergies and autoimmune diseases, in particular rheumatoid arthritis, multiple sclerosis or Crohn's disease, chronic inflammation, asthma, immune deficiency diseases, AIDS, transplant rejection, cancer diseases and diabetes.
Abstract translation: 本发明涉及含有半乳凝素的调节性T细胞，特别是其用作标记物，以及用于治疗和诊断疾病，特别是过敏和自身免疫疾病，特别是类风湿性关节炎，多发性硬化或克罗恩病，慢性炎症 ，哮喘，免疫缺陷病，艾滋病，移植排斥，癌症和糖尿病。
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4.发明授权Screening method for the identification of agents capable of activating CD4+CD25+ regulatory T-cells through interactions with the HIV-1 GP120 binding site on CD4 有权通过与HIV-1 GP120结合位点在CD4上相互作用鉴定能够激活CD4 + CD25 +调节性T细胞的药剂的筛选方法公开(公告)号：US08557533B2
公开(公告)日：2013-10-15
申请号：US12525142
申请日：2008-01-30
Applicant: Franz-Josef Schneider , Christian Becker , Tobias Bopp , Helmut Jonuleit , Edgar Schmitt
Inventor： Franz-Josef Schneider , Christian Becker , Tobias Bopp , Helmut Jonuleit , Edgar Schmitt
CPC classification number: A61K38/162 , A61K38/00 , C07K14/005 , C07K16/18 , C12N7/00 , C12N2740/16033 , C12N2740/16111 , C12N2740/16122 , G01N33/505 , G01N2333/162 , G01N2333/7051
Abstract: The present invention relates specific activation of a regulatory T cell via a specific CD4 epitope and uses thereof, e.g. for the treatment of an autoimmune disease or an allergy or asthma or graft rejection or tolerance induction.
Abstract translation: 本发明涉及经由特异性CD4表位的调节性T细胞的特异性活化及其用途，例如， 用于治疗自身免疫性疾病或过敏或哮喘或移植排斥反应或耐受性诱导。
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公开(公告)号：US20090208496A1
公开(公告)日：2009-08-20
申请号：US12392521
申请日：2009-02-25
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: A61K39/395 , C12N5/02
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
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Patent Agency Ranking
公开(公告)号：US07452981B2
公开(公告)日：2008-11-18
申请号：US11217402
申请日：2005-09-02
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: C07K16/28
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Abstract translation: 衍生自小鼠单克隆抗CD4抗体B-F5的人源化抗体能够激活CD25 + CD4 +调节性T细胞，并且可用于制备免疫抑制组合物。
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公开(公告)号：US08673304B2
公开(公告)日：2014-03-18
申请号：US12392521
申请日：2009-02-25
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: A61K39/395
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Abstract translation: 衍生自小鼠单克隆抗CD4抗体B-F5的人源化抗体能够激活CD25 + CD4 +调节性T细胞，并且可用于制备免疫抑制组合物。
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公开(公告)号：US20100291676A1
公开(公告)日：2010-11-18
申请号：US12392493
申请日：2009-02-25
Applicant: JOHN WIJDENES , HELMUT JONULEIT
Inventor： JOHN WIJDENES , HELMUT JONULEIT
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Abstract translation: 衍生自小鼠单克隆抗CD4抗体B-F5的人源化抗体能够激活CD25 + CD4 +调节性T细胞，并且可用于制备免疫抑制组合物。
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公开(公告)号：US20090208497A1
公开(公告)日：2009-08-20
申请号：US12392556
申请日：2009-02-25
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: A61K39/395 , G01N33/567 , C07K16/00
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
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公开(公告)号：US08586715B2
公开(公告)日：2013-11-19
申请号：US12246660
申请日：2008-10-07
Applicant: John Wijdenes , Helmut Jonuleit
Inventor： John Wijdenes , Helmut Jonuleit
IPC: C07K16/28
CPC classification number: C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
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