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    1H-Imidazo[4,5-C]Quinoline Derivatives in the Treatment of Protein Kinase Dependent Diseases
    1.
    发明申请
    1H-Imidazo[4,5-C]Quinoline Derivatives in the Treatment of Protein Kinase Dependent Diseases 审中-公开
    1H-咪唑并[4,5-C]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用

    公开(公告)号：US20070213355A1

    公开(公告)日：2007-09-13

    申请号：US10579876

    申请日：2004-11-19

    申请人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Cheverria ,  Frederic Stauffer

    发明人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Cheverria ,  Frederic Stauffer

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04 ,  A61K31/41

    摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

    摘要翻译： 本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉， 所述疾病包括向包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的温血动物，特别是人的药物制剂，以及制备新的咪唑并喹啉的方法施用咪唑并喹啉。

    PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS
    2.
    发明申请
    PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS 审中-公开
    作为脂质激酶抑制剂的吡唑并嘧啶

    公开(公告)号：US20090286779A1

    公开(公告)日：2009-11-19

    申请号：US12442606

    申请日：2007-09-27

    申请人： Patricia Imbach ,  Frederic Stauffer ,  Pascal Furet ,  Hans-Georg Capraro

    发明人： Patricia Imbach ,  Frederic Stauffer ,  Pascal Furet ,  Hans-Georg Capraro

    IPC分类号： A61K31/5377 ,  C07D487/04 ,  C07D401/12 ,  C07D413/14 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： The invention relates to novel—at least 3,5-disubstituted-pyrazolo[1,5-a]pyrimidines of the formula I, wherein the symbols R1 to R4 are as defined in the specification, tautomers thereof or N-oxides thereof, or (preferably pharmaceutically acceptable) salts thereof, or hydrates or solvates thereof, as well as to related embodiments. The compounds are useful inter alia as protein kinase inhibitors, and thus e.g. useful in the treatment of diseases that respond to an inhibition of kinases of the PI3-kinase-related protein kinase family, especially lipid kinases and/or PI3 kinase (PI3K) and/or mTOR and/or DNA protein kinase and/or ATM and/or ATR and/or hSMG-1.

    摘要翻译： 本发明涉及式I的至少3,5-二取代 - 吡唑并[1,5-a]嘧啶，其中符号R1至R4如本说明书中所定义，其互变异构体或其N-氧化物，或 （优选药学上可接受的）盐，或其水合物或溶剂化物，以及相关实施方案。 所述化合物尤其可用作蛋白激酶抑制剂， 可用于治疗响应抑制PI3激酶相关蛋白激酶家族，特别是脂质激酶和/或PI3激酶（PI3K）和/或mTOR和/或DNA蛋白激酶和/或ATM的激酶的疾病，以及 /或ATR和/或hSMG-1。

    3-Methyl-imidazo[1,2-b]pyridazine derivatives
    4.
    发明授权
    3-Methyl-imidazo[1,2-b]pyridazine derivatives 有权
    3-甲基 - 咪唑并[1,2-b]哒嗪衍生物

    公开(公告)号：US08822468B2

    公开(公告)日：2014-09-02

    申请号：US12396137

    申请日：2009-03-02

    申请人： Pascal Furet ,  Clive McCarthy ,  Joseph Schoepfer ,  Carsten Spanka ,  Melanie Stang ,  Frederic Stauffer

    发明人： Pascal Furet ,  Clive McCarthy ,  Joseph Schoepfer ,  Carsten Spanka ,  Melanie Stang ,  Frederic Stauffer

    IPC分类号： C07D519/00 ,  C07D487/04 ,  A61K31/5025 ,  A61P35/00

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).

    摘要翻译： 本发明涉及式（I）化合物及其盐，其中取代基如本说明书中所定义，式（I）化合物在治疗人或动物体的方法中的应用，特别是关于 对C-Met酪氨酸激酶介导的疾病; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物的药物组合物，任选地在组合配偶体存在下; 制备式（I）化合物的方法。

    1H-IMIDAZO[4,5-C]QUINOLINONE DERIVATIVES
    8.
    发明申请
    1H-IMIDAZO[4,5-C]QUINOLINONE DERIVATIVES 审中-公开
    1H-咪唑并[4,5-C]喹啉酮衍生物

    公开(公告)号：US20140005163A1

    公开(公告)日：2014-01-02

    申请号：US13901849

    申请日：2013-05-24

    申请人： Pascal Furet ,  Frank Stephan Kalthoff ,  Robert Mah ,  Christian Ragot ,  Frederic Stauffer

    发明人： Pascal Furet ,  Frank Stephan Kalthoff ,  Robert Mah ,  Christian Ragot ,  Frederic Stauffer

    IPC分类号： C07D471/04 ,  C07D498/04

    CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D498/04

    摘要： The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone derivatives; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone derivatives.

    摘要翻译： 本发明涉及1H-咪唑并[4,5-c]喹啉酮衍生物及其盐在治疗蛋白质和/或脂质激酶依赖性疾病中的用途以及制备用于治疗所述疾病的药物制剂; 用于治疗蛋白质和/或脂质激酶依赖性疾病的1H-咪唑并[4,5-c]喹啉酮衍生物; 一种治疗所述疾病的方法，包括将1H-咪唑并[4,5-c]喹啉酮衍生物给予温血动物，特别是人; 包含1H-咪唑并[4,5-c]喹啉酮衍生物的药物制剂，特别是用于治疗蛋白质和/或脂质激酶依赖性疾病; 新型1H-咪唑并[4,5-c]喹啉酮衍生物; 以及制备新的1H-咪唑并[4,5-c]喹啉酮衍生物的方法。

    1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase inhibitors
    9.
    发明授权
    1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase inhibitors 有权
    1,3-二氢 - 咪唑并[4,5-c]喹啉-2-酮作为脂质激酶抑制剂

    公开(公告)号：US08431592B2

    公开(公告)日：2013-04-30

    申请号：US13165144

    申请日：2011-06-21

    申请人： Carlos Garcia-Echeverria ,  Frederic Stauffer ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Frederic Stauffer ,  Pascal Furet

    IPC分类号： A61K31/4188

    CPC分类号： C07D471/04

    摘要： The invention relates to methods of treatment of a proliferative disease which responds to inhibition of PI3-Kinase-related protein kinases, particularly the PI3-kinase, by administration of a novel organic compound of formula (I) to a human or animal requiring such treatment; and methods of treatment of inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease, by administration of such compound.

    摘要翻译： 本发明涉及通过向需要这种治疗的人或动物施用式（I）的新型有机化合物来治疗对PI3-激酶相关蛋白激酶，特别是PI3激酶的抑制作用的增殖性疾病的治疗方法 ; 以及通过施用该化合物治疗炎性或阻塞性气道疾病如哮喘，通常与移植相关的疾病或增生性疾病如肿瘤疾病的治疗方法。