公开(公告)号：US5869481A

公开(公告)日：1999-02-09

申请号：US93897

申请日：1998-06-09

申请人： Hans-Joachim Lankau ,  Manfred Menzer ,  Klaus Unverferth ,  Karl Gewald ,  Harry Schafer, deceased

发明人： Hans-Joachim Lankau ,  Manfred Menzer ,  Klaus Unverferth ,  Karl Gewald ,  Harry Schafer, deceased

IPC分类号： A61K31/415 ,  A61K31/435 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  C07D233/66 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

CPC分类号： A61K31/415 ,  A61K31/435 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  C07D233/66 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04

摘要： Compounds having anticonsulive activity, of the formula 1 ##STR1## in which X is hydrogen, a C.sub.1-4 -alkyl, C.sub.1-4 alkoxy, trifluoromethyl, or halogen residue, R.sup.1 and R.sup.2 are independently of each other C.sub.1-4 -alkyl, C.sub.2-4 hydroxyalkyl, cycloalkyl or heteroalkyl, or R.sup.1 and R.sup.2 are together a C.sub.2-6 alkylene reside in which a--CH.sub.2 --group is optionally replaced by oxygen, nitrogen or sulfur, m is 0 or 1, and n is 0 or a cardinal number from 1 to 5, and their pharmaceutically acceptable salts. The application also relates to a process for making the compound of formula (I).

摘要翻译： 具有防腐活性的化合物，其中X为氢，C 1-4 - 烷基，C 1-4烷氧基，三氟甲基或卤素残基，其中R 1和R 2彼此独立地为C 1-4 - 烷基，C2-4羟烷基，环烷基或杂烷基，或R1和R2一起是C2-6亚烷基，其中a-CH2-基团任选被氧，氮或硫取代，m为0或1，n为 0或1至5的基数，及其药学上可接受的盐。 本申请还涉及制备式（I）化合物的方法。