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1.
公开(公告)号:US20090197882A1
公开(公告)日:2009-08-06
申请号:US12307030
申请日:2007-06-18
IPC分类号: A61K31/416 , A61K31/5355 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/4184 , C07D413/12 , C07D401/12 , C07D231/56 , A61P35/00 , C07D403/12 , C07D405/12
CPC分类号: C07D403/12 , C07D231/56 , C07D405/12
摘要: Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim (1), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新型吲唑衍生物,其中R1-R3具有权利要求(1)所示的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节和 /或HSP90调节起作用。
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公开(公告)号:US07906657B2
公开(公告)日:2011-03-15
申请号:US12301067
申请日:2007-04-20
IPC分类号: C07D261/06 , C07D231/12 , C07D401/10 , C07D403/10 , A61K31/501 , A61K31/497 , A61K31/454 , A61K31/4427 , A61K31/415
CPC分类号: C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新的1,5-二苯基吡唑衍生物,其中R 1 -R 6具有权利要求1所述的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节 和/或调节HSP90起作用。
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公开(公告)号:US08816070B2
公开(公告)日:2014-08-26
申请号:US12523387
申请日:2007-12-11
IPC分类号: A61K31/4196 , C07D249/08 , C07D249/12
CPC分类号: C07D249/12
摘要: 5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 5- [4-(2-甲基苯基)-3-羟基-4H-1,2,4-三唑-5-基] -2,4-二羟基-N-甲基-N-丁基苯甲酰胺是HSP90抑制剂,可以是 用于制备用于治疗其中HSP90的抑制,调节和/或调节起作用的疾病的药物的制备。
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公开(公告)号:US08119795B2
公开(公告)日:2012-02-21
申请号:US12301140
申请日:2007-04-20
IPC分类号: A61K31/4196 , C07D503/12 , C07D249/12 , C07D401/12
CPC分类号: C07D249/08 , C07D401/12 , C07D403/12
摘要: Novel triazole derivatives of the formula (I) in which R1-R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新型三唑衍生物,其中R 1 -R 6和Y具有权利要求1所述的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节和/ 或调制HSP90起作用。
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公开(公告)号:US20110028485A1
公开(公告)日:2011-02-03
申请号:US12883428
申请日:2010-09-16
IPC分类号: A61K31/415 , C07D231/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/496 , A61K31/4439 , A61K31/422 , A61K31/501 , A61K31/497 , A61P35/00 , A61P35/04 , A61P37/00 , A61P31/00 , A61P9/10 , A61P31/12 , A61P3/10 , A61P11/06 , A61P17/06 , A61P25/00 , A61P1/00
CPC分类号: C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新的1,5-二苯基吡唑衍生物,其中R 1 -R 6具有权利要求1所述的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节 和/或调节HSP90起作用。
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公开(公告)号:US20100113542A1
公开(公告)日:2010-05-06
申请号:US12523387
申请日:2007-12-11
IPC分类号: A61K31/4196 , A61P31/12 , A61P35/00 , A61P37/00 , C07D249/08 , C07F9/06 , C07D249/12 , C07H17/02
CPC分类号: C07D249/12
摘要: 5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 5- [4-(2-甲基苯基)-3-羟基-4H-1,2,4-三唑-5-基] -2,4-二羟基-N-甲基-N-丁基苯甲酰胺是HSP90抑制剂,可以是 用于制备用于治疗其中HSP90的抑制,调节和/或调节起作用的疾病的药物的制备。
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公开(公告)号:US20090325974A1
公开(公告)日:2009-12-31
申请号:US12301067
申请日:2007-04-20
IPC分类号: A61K31/501 , C07D231/12 , A61K31/415 , A61K31/496 , C07D403/12 , A61P35/00
CPC分类号: C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新的1,5-二苯基吡唑衍生物,其中R 1 -R 6具有权利要求1所示的含义,是HSP90抑制剂,可用于制备用于治疗其抑制,调节 和/或调节HSP90起作用。
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8.
公开(公告)号:US08722903B2
公开(公告)日:2014-05-13
申请号:US12307030
申请日:2007-06-18
IPC分类号: C07D231/56 , A61K31/44
CPC分类号: C07D403/12 , C07D231/56 , C07D405/12
摘要: Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim (1), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新型吲唑衍生物,其中R1-R3具有权利要求(1)所示的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节和 /或HSP90调节起作用。
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公开(公告)号:US20100022540A1
公开(公告)日:2010-01-28
申请号:US12301140
申请日:2007-04-20
IPC分类号: A61K31/4196 , C07D503/12 , C07D249/12 , C07D401/12 , C07D413/12 , C07D403/12 , A61K31/496 , A61K31/4439 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P31/12 , A61P25/00
CPC分类号: C07D249/08 , C07D401/12 , C07D403/12
摘要: Novel triazole derivatives of the formula (I) in which R1—R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新型三唑衍生物,其中R 1 -R 6和Y具有权利要求1所述的含义,是HSP90抑制剂,可用于制备用于治疗其中抑制,调节和/ 或调制HSP90起作用。
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公开(公告)号:US20100160352A1
公开(公告)日:2010-06-24
申请号:US12063384
申请日:2006-07-20
IPC分类号: A61K31/52 , C07D473/34 , A61P25/28
CPC分类号: C07D473/34
摘要: Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译: 式(I)的新型腺嘌呤衍生物,其中R 1,R 2,R 3,X和Y具有权利要求1所示的含义,是HSP90抑制剂,可用于制备用于治疗疾病的药物 HSP90的抑制,调节和/或调节起着重要的作用。
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