利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.028 秒)

    Methods of treating vascular disease associated with cystatin C deficiency
    1.
    发明授权
    Methods of treating vascular disease associated with cystatin C deficiency 失效
    治疗与半胱氨酸蛋白酶抑制剂C缺乏相关的血管疾病的方法

    公开(公告)号：US06773704B1

    公开(公告)日：2004-08-10

    申请号：US09697613

    申请日：2000-10-26

    申请人： Harold A. Chapman ,  Guo-Ping Shi ,  Peter Libby ,  Galina K. Sukhova ,  Daniel I. Simon

    发明人： Harold A. Chapman ,  Guo-Ping Shi ,  Peter Libby ,  Galina K. Sukhova ,  Daniel I. Simon

    IPC分类号： A61K3816

    CPC分类号： A61K38/1841 ,  A61K38/57

    摘要： The invention provides methods of treating and preventing vascular diseases, by inhibiting cysteine proteases active at sites of vascular injury, particularly cathepsins K and S, by administering cystatin C or TGF-&bgr;1. Cystatin C is severely reduced in both atherosclerotic and aneurysmal aortic lesions. Also provided is a method of diagnosing a patient at risk of, or with, vascular injury by detecting low levels of circulating cystatin C.

    摘要翻译： 本发明通过施用半胱氨酸蛋白酶抑制剂C或TGF-β1，通过抑制在血管损伤部位活化的半胱氨酸蛋白酶，特别是组织蛋白酶K和S来提供治疗和预防血管疾病的方法。 动脉粥样硬化和动脉瘤主动脉瘤病变中半胱氨酸蛋白酶抑制剂C都严重降低。 还提供了一种通过检测低水平的循环半胱氨酸蛋白酶抑制剂C来诊断患有血管损伤或伴有血管损伤的患者的方法。

    Treatment and prevention of cardiovascular disease using mast cell stabilizers
    3.
    发明授权
    Treatment and prevention of cardiovascular disease using mast cell stabilizers 有权
    使用肥大细胞稳定剂治疗和预防心血管疾病

    公开(公告)号：US08445437B2

    公开(公告)日：2013-05-21

    申请号：US11878419

    申请日：2007-07-24

    申请人： Guo-Ping Shi

    发明人： Guo-Ping Shi

    IPC分类号： A61K38/00 ,  A61K31/35 ,  A61K31/12 ,  A61P9/00 ,  A01N43/16 ,  A01N35/00

    CPC分类号： A61K31/35 ,  A61K31/44

    摘要： The present invention is directed to methods of treating or preventing the development of cardiovascular disease by administering compounds that stabilize mast cells. In addition, it includes pharmaceutical compositions which have both a mast cell stabilizer and instructions regarding the use of the stabilizer in treating or preventing cardiovascular disease. The methods and compositions will be of particular value for preventing aneurysms of the abdominal aorta in individuals with atherosclerosis, diabetes, hypertension or a family history of aneurysms.

    摘要翻译： 本发明涉及通过施用稳定肥大细胞的化合物来治疗或预防心血管疾病发展的方法。 此外，它包括具有肥大细胞稳定剂和关于使用稳定剂治疗或预防心血管疾病的说明书的药物组合物。 该方法和组合物对于预防动脉粥样硬化，糖尿病，高血压或动脉瘤家族史的腹主动脉瘤的动脉瘤具有特别的价值。

    Method and composition for treating obesity by targeting cathespin
    4.
    发明申请
    Method and composition for treating obesity by targeting cathespin 审中-公开
    通过靶向治疗肥胖症的方法和组合物

    公开(公告)号：US20070123483A1

    公开(公告)日：2007-05-31

    申请号：US11526221

    申请日：2006-09-22

    申请人： Guo-Ping Shi

    发明人： Guo-Ping Shi

    IPC分类号： A61K48/00

    CPC分类号： C12N9/6472 ,  A61K31/325 ,  A61K31/336 ,  A61K31/396 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4433 ,  A61K31/537 ,  A61K38/05 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/75 ,  C12Y304/22015 ,  C12Y304/22027 ,  C12Y304/22038

    摘要： Methods and compositions are provided for modulating fat storage of animals by targeting the gene and gene products of cathepsins, particularly cathepsins L, K, and S. The method comprises: administering to the animal an agent that reduces an in vivo level of cathepsin L activity such that fat storage by the animal is reduced. The methods of the present invention can be used to diagnose obesity, diabetes and related diseases such as hyperinsulinmia, hyperglycermia, hypertension, cardiovascular diseases, muscular dystrophy and infertility, as well as screen for agents that can be used threapeutics for these diseases.

    摘要翻译： 提供了通过靶向组织蛋白酶，特别是组织蛋白酶L，K和S的基因和基因产物来调节动物的脂肪储存的方法和组合物。该方法包括：向动物施用降低组织蛋白酶L活性的体内水平的试剂 使得动物的脂肪储存减少。 本发明的方法可用于诊断肥胖症，糖尿病和相关疾病，例如高胰岛素血症，高糖，高血压，心血管疾病，肌营养不良和不育症，以及筛选可用于治疗这些疾病的药物。

    Mast cell stabilizers in the treatment of obesity
    7.
    发明申请
    Mast cell stabilizers in the treatment of obesity 有权
    肥大细胞稳定剂治疗肥胖

    公开(公告)号：US20090093511A1

    公开(公告)日：2009-04-09

    申请号：US12232789

    申请日：2008-09-24

    申请人： Guo-Ping Shi

    发明人： Guo-Ping Shi

    IPC分类号： A61K31/352 ,  A61K31/436 ,  A61K31/4535 ,  A61K31/195 ,  A61P3/04

    CPC分类号： A61K31/4741 ,  A61K31/195 ,  A61K31/277 ,  A61K31/352 ,  A61K31/436 ,  A61K31/4535

    摘要： The present invention is directed to methods of treating or preventing the development of obesity by administering compounds that stabilize mast cells. In addition, it includes pharmaceutical compositions which have both a mast cell stabilizer and instructions regarding the use of the stabilizer in treating or preventing obesity.

    摘要翻译： 本发明涉及通过施用稳定肥大细胞的化合物来治疗或预防肥胖症发展的方法。 此外，它包括具有肥大细胞稳定剂和关于使用稳定剂治疗或预防肥胖症的说明书的药物组合物。

    Treatment and prevention of cardiovascular disease using mast cell stabilizers
    9.
    发明申请
    Treatment and prevention of cardiovascular disease using mast cell stabilizers 有权
    使用肥大细胞稳定剂治疗和预防心血管疾病

    公开(公告)号：US20080027111A1

    公开(公告)日：2008-01-31

    申请号：US11878419

    申请日：2007-07-24

    申请人： Guo-Ping Shi

    发明人： Guo-Ping Shi

    IPC分类号： A61K31/44 ,  A61K31/35 ,  A61P9/00

    CPC分类号： A61K31/35 ,  A61K31/44

    摘要： The present invention is directed to methods of treating or preventing the development of cardiovascular disease by administering compounds that stabilize mast cells. In addition, it includes pharmaceutical compositions which have both a mast cell stabilizer and instructions regarding the use of the stabilizer in treating or preventing cardiovascular disease. The methods and compositions will be of particular value for preventing aneurysms of the abdominal aorta in individuals with atherosclerosis, diabetes, hypertension or a family history of aneurysms.

    摘要翻译： 本发明涉及通过施用稳定肥大细胞的化合物来治疗或预防心血管疾病发展的方法。 此外，它包括具有肥大细胞稳定剂和关于使用稳定剂治疗或预防心血管疾病的说明书的药物组合物。 该方法和组合物对于预防动脉粥样硬化，糖尿病，高血压或动脉瘤家族史的腹主动脉瘤的动脉瘤具有特别的价值。