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公开(公告)号:US20070112180A1
公开(公告)日:2007-05-17
申请号:US11512765
申请日:2006-08-29
申请人: Harry Gray , Brian Crane , Jay Winkler , Ivan Dmochowski , Jonathan Wilker , Alexander Dunn
发明人: Harry Gray , Brian Crane , Jay Winkler , Ivan Dmochowski , Jonathan Wilker , Alexander Dunn
IPC分类号: C07K16/00
CPC分类号: C12Q1/26 , G01N33/542 , G01N33/582 , G01N2333/795 , G01N2333/80 , G01N2333/90245
摘要: Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included.
摘要翻译: 公开了使用敏化剂连接的底物分子检测和表征靶生物分子的方法和组合物。 还包括本发明的高通量筛选测定和治疗应用。
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公开(公告)号:US5415042A
公开(公告)日:1995-05-16
申请号:US39446
申请日:1993-04-22
申请人: Harry Gray , Barry L. Price
发明人: Harry Gray , Barry L. Price
CPC分类号: G01F23/00 , G01F23/241 , G01F23/242
摘要: A measuring probe to detect the presence of electrically conducting liquid or granular material includes a first metal electrode (4) comprising a tube (5) which is adhered to a porous, ceramic insulator (12) adhered in turn to a skirt (10) forming a second metal electrode (6). First electrode (4) is connected to a gas supply (58) supplying gas, for example nitrogen, under pressure which emerges into a space (26) in the probe and which then passes through insulator (12) to emerge from face (20) thereof. A heat resistant cable (46) has its conductor (52) brazed to cap portion (8) of second electrode (6). Cable (46) and first electrode (4) are connected into an electrical circuit (66) in which current flows when a conducting bridge of granular material simultaneously contacts both electrodes (4 and 6). Should the level of the granular material drop below second electrode (6), gas emerging from face (20) blows away any granular material trying to preserve the conducting bridge, and circuit (66) is interrupted.
摘要翻译: PCT No.PCT / GB91 / 01971 Sec。 371日期:1993年4月22日 102(e)日期1993年4月22日PCT 1991年11月8日PCT PCT。 出版物WO92 / 09868 日期:1992年6月11日。用于检测导电液体或颗粒材料的存在的测量探针包括第一金属电极(4),其包括管(5),所述管(5)依次粘附到多孔陶瓷绝缘体(12) 到形成第二金属电极(6)的裙部(10)。 第一电极(4)连接到在压力下供应气体(例如氮气)的气体供应源58,该压力出现在探针中的空间(26)中,然后通过绝缘体(12)从表面(20)露出, 其中。 耐热电缆(46)具有钎焊到第二电极(6)的盖部分(8)上的导体(52)。 电缆(46)和第一电极(4)连接到电路(66)中,其中当颗粒材料的导电桥同时接触两个电极(4和6)时,电流流过电流。 如果粒状材料的水平下降到第二电极(6)的下方,则从面(20)排出的气体会吹走任何试图保留导电桥的颗粒材料,并且电路(66)被中断。
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