公开(公告)号：US4083951A

公开(公告)日：1978-04-11

申请号：US792118

申请日：1977-04-29

Applicant: Alexander Crossan Goudie ,  Harry Seager ,  Howard Fisher

Inventor： Alexander Crossan Goudie ,  Harry Seager ,  Howard Fisher

IPC: A61K31/60 ,  A61K9/46 ,  A61K33/26 ,  A61P25/04 ,  A61P29/00 ,  A61L9/04

CPC classification number: A61K31/60 ,  A61K33/26 ,  A61K9/0007

Abstract: Pharmaceutical compositions containing acetyl salicylic acid or a salt thereof and a ferrous salt having 1 to 7 equivalents of acetyl salicylic acid per equivalent of ferrous ion and characterized by reduced gastric irritation without major reduction of the usual properties of the acetyl salicylic acid. The compositions are orally administrable and may be formulated in one part or in multi-parts with the parts physically separated to prevent premature reaction particularly when the composition is effervescent.

Abstract translation: 含有乙酰水杨酸或其盐的药物组合物和每当量亚铁离子具有1至7当量乙酰水杨酸的亚铁盐，其特征在于减少胃刺激而不会大幅降低乙酰水杨酸的通常性质。 组合物可口服施用，并且可以配制成一部分或多部分，其中物理分离的部分防止过早反应，特别是当组合物是泡腾时。

公开(公告)号：US4016254A

公开(公告)日：1977-04-05

申请号：US673441

申请日：1976-04-05

Applicant: Harry Seager

Inventor： Harry Seager

IPC: A61K9/20 ,  A61K9/50 ,  B01J13/04 ,  A61K31/43 ,  A61K31/79

CPC classification number: B01J13/043 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5057 ,  A61K9/5089 ,  Y10T428/2989

Abstract: Microcapsules which have an average diameter of from 100.mu. to 300.mu. and which comprise 94% to 99.9% of a medicament coated by 0.1% to 6% of a coating agent may be formed into a powder with 0% to 95% excipients or a tablet or capsule with a carrier.

Abstract translation: 平均直径为100〜300μm，含有0.1〜6％涂布剂的药物的94〜99.9％的微胶囊可以形成为含有0〜95％的赋形剂或 片剂或胶囊与载体。