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公开(公告)号：US09211258B2
公开(公告)日：2015-12-15
申请号：US13583769
申请日：2011-03-09
IPC分类号： A61K31/44 , A61K9/10 , A61K31/428
CPC分类号： A61K31/437 , A23L27/00 , A23V2002/00 , A61K9/10 , A61K31/428
摘要： A stable, taste-masked, ready-to-use suspension comprising rifaximin dispersed in a suspension base and one or more pharmaceutically acceptable additive(s). Also provided is a process for preparing a stable, taste-masked, ready-to-use suspension of rifaximin comprising the steps of mixing rifaximin with the suspension base and further sizing the particles of rifaximin by milling the suspension to obtain a homogenously dispersed rifaximin suspension.
摘要翻译： 包含分散在悬浮液中的利福昔明和一种或多种药学上可接受的添加剂的稳定的，掩味的即用型悬浮液。 还提供了制备利福昔明的稳定的，掩味的即用型悬浮液的方法，包括以下步骤：将利福昔明与悬浮液基体混合，并通过研磨悬浮液进一步调节利福昔明颗粒，获得均匀分散的利福昔明悬浮液 。
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公开(公告)号：US20130072512A1
公开(公告)日：2013-03-21
申请号：US13583769
申请日：2011-03-09
IPC分类号： A61K31/437 , A61P31/04
CPC分类号： A61K31/437 , A23L27/00 , A23V2002/00 , A61K9/10 , A61K31/428
摘要： A stable, taste-masked, ready-to-use suspension comprising rifaximin dispersed in a suspension base and one or more pharmaceutically acceptable additive(s). Also provided is a process for preparing a stable, taste-masked, ready-to-use suspension of rifaximin comprising the steps of mixing rifaximin with the suspension base and further sizing the particles of rifaximin by milling the suspension to obtain a homogenously dispersed rifaximin suspension.
摘要翻译： 包含分散在悬浮液基中的利福昔明和一种或多种药学上可接受的添加剂的稳定的，掩味的即用型悬浮液。 还提供了制备利福昔明的稳定的，掩味的即用型悬浮液的方法，包括以下步骤：将利福昔明与悬浮液基体混合，并通过研磨悬浮液进一步调节利福昔明颗粒，获得均匀分散的利福昔明悬浮液 。
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公开(公告)号：US10786464B2
公开(公告)日：2020-09-29
申请号：US13505990
申请日：2010-11-03
摘要： The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.
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公开(公告)号：US20120219631A1
公开(公告)日：2012-08-30
申请号：US13505990
申请日：2010-11-03
IPC分类号： A61K31/165 , A61P25/08 , A61K9/14
摘要： The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.
摘要翻译： 本发明提供了漆酶的改良释放制剂。 包含lacosamide和改性释放聚合物的本发明的改进释放制剂在至少12小时的时间段内提供了具有最小C max至C min峰到谷变化的lacosamide的改进释放。
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