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1.发明申请METHOD OF TREATING DERMATITIS COMPRISING ADMINISTERING A CHYMASE INHIBITOR 审中-公开治疗包含乙型肝炎病毒抑制剂的药物治疗方法公开(公告)号：US20100029695A1
公开(公告)日：2010-02-04
申请号：US12576829
申请日：2009-10-09
IPC分类号： A61K31/517 , A61P37/06 , A61P17/02
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517
摘要： A medicament safe and free from side effects, for the prevention or treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, which suppresses the progress of the condition and improves the quality of life of the patient, which medicament treats dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen by including a quiazoline derivative having the formula (I) or (II) or its pharmaceutically acceptable salt as an effective ingredient:
摘要翻译： 一种安全且无副作用的药物，用于预防或治疗由于反复接触抗原而引起的双相炎症反应或皮炎，其抑制病症的进展并改善患者的生活质量，该药物 通过包括具有式（I）或（II）的喹唑啉衍生物或其药学上可接受的盐作为有效成分，治疗通过重复暴露于抗原而引起的双相炎症反应或皮炎的皮炎，
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2.发明授权公开(公告)号：US07618977B2
公开(公告)日：2009-11-17
申请号：US09959252
申请日：2001-02-22
IPC分类号： A61K31/517 , A61K31/535
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517
摘要： Medicaments for the treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, having quinazolidone derivatives of formula I or II that are herein defined, are disclosed.
摘要翻译： 公开了用于治疗皮炎的药物，其显示出通过重复接触抗原诱导的双相炎症反应或皮炎，其具有本文定义的式I或II的喹唑酮酮衍生物。
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3.发明申请7-membered ring compound and method of production and pharmaceutical application thereof 有权7-元环化合物及其制备方法及其药物应用公开(公告)号：US20090111796A1
公开(公告)日：2009-04-30
申请号：US11791828
申请日：2005-12-01
IPC分类号： A61K31/551 , C07D243/08 , C07D401/06 , C07D403/06 , C07D413/06
CPC分类号： C07D243/08 , C07C233/47 , C07C271/22 , C07D213/79 , C07D213/80 , C07D243/10 , C07D307/68 , C07D333/40 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
摘要翻译： 具有式（I）的7元杂环化合物或其盐或其具有糜酶抑制作用的溶剂化物并且可用于预防或治疗涉及糜酶的各种疾病：其制备方法， 以及可用于预防或治疗其中涉及胃促胰酶的药物组合物，包括具有式（I）的化合物或其药学上可接受的盐或溶剂合物。
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4.发明申请7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF 失效7-会员环化合物及其生产方法和药物应用公开(公告)号：US20110166342A1
公开(公告)日：2011-07-07
申请号：US12984195
申请日：2011-01-04
IPC分类号： C07D243/08 , C07C311/16 , C07D213/71 , C07C311/24 , C07D401/02 , C07C229/34 , C07C271/28
CPC分类号： C07D243/08 , C07C233/47 , C07C271/22 , C07D213/79 , C07D213/80 , C07D243/10 , C07D307/68 , C07D333/40 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
摘要翻译： 具有式（I）的7元杂环化合物或其盐或其具有糜酶抑制作用的溶剂化物并且可用于预防或治疗涉及糜酶的各种疾病：其制备方法， 以及可用于预防或治疗其中涉及胃促胰酶的药物组合物，包括具有式（I）的化合物或其药学上可接受的盐或溶剂合物。
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公开(公告)号：US08049006B2
公开(公告)日：2011-11-01
申请号：US12302646
申请日：2007-05-30
申请人： Tsuyoshi Muto , Taisaku Tanaka , Hiroshi Maruoka , Seiichi Imajo , Yoshiaki Tomimori , Koji Sato , Tsutomu Yagi
发明人： Tsuyoshi Muto , Taisaku Tanaka , Hiroshi Maruoka , Seiichi Imajo , Yoshiaki Tomimori , Koji Sato , Tsutomu Yagi
IPC分类号： C07D243/08
CPC分类号： C07D243/08 , C07D243/10 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
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6.发明申请7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF 失效7-会员环化合物及其生产方法和药物应用公开(公告)号：US20090253683A1
公开(公告)日：2009-10-08
申请号：US12302646
申请日：2007-05-30
申请人： Tsuyoshi Muto , Taisaku Tanaka , Hiroshi Maruoka , Seiichi Imajo , Yoshiaki Tomimori , Koji Sato , Tsutomu Yagi
发明人： Tsuyoshi Muto , Taisaku Tanaka , Hiroshi Maruoka , Seiichi Imajo , Yoshiaki Tomimori , Koji Sato , Tsutomu Yagi
IPC分类号： A61K31/551 , C07D243/08 , A61P9/00 , A61P27/00 , A61P17/00
CPC分类号： C07D243/08 , C07D243/10 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
摘要翻译： 具有式（I）的7元杂环化合物或其盐或其具有糜酶抑制作用的溶剂化物并且可用于预防或治疗涉及糜酶的各种疾病：其制备方法， 以及可用于预防或治疗其中涉及胃促胰酶的药物组合物，包括具有式（I）的化合物或其药学上可接受的盐或溶剂合物。
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公开(公告)号：US08507714B2
公开(公告)日：2013-08-13
申请号：US12984195
申请日：2011-01-04
IPC分类号： C07C229/38
CPC分类号： C07D243/08 , C07C233/47 , C07C271/22 , C07D213/79 , C07D213/80 , C07D243/10 , C07D307/68 , C07D333/40 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
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8.发明授权7-membered ring compound and method of production and pharmaceutical application thereof 有权7-元环化合物及其制备方法及其药物应用公开(公告)号：US07888348B2
公开(公告)日：2011-02-15
申请号：US11791828
申请日：2005-12-01
IPC分类号： C07D243/08 , C07D401/06 , C07D403/12 , A61K31/551 , A61P9/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P41/00
CPC分类号： C07D243/08 , C07C233/47 , C07C271/22 , C07D213/79 , C07D213/80 , C07D243/10 , C07D307/68 , C07D333/40 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
摘要翻译： 具有式（I）的7元杂环化合物或其盐或其具有糜酶抑制作用的溶剂化物并且可用于预防或治疗涉及糜酶的各种疾病：其制备方法， 以及可用于预防或治疗其中涉及胃促胰酶的药物组合物，包括具有式（I）的化合物或其药学上可接受的盐或溶剂合物。
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