公开(公告)号：US06317732B1

公开(公告)日：2001-11-13

申请号：US08925186

申请日：1997-09-08

申请人： Haruki Inoue ,  Mayumi Mizutani ,  Masami Shiozawa ,  Satoru Yoshikawa

发明人： Haruki Inoue ,  Mayumi Mizutani ,  Masami Shiozawa ,  Satoru Yoshikawa

IPC分类号： G06N312

CPC分类号： G06Q10/06 ,  Y10S707/99933

摘要： A planning system includes an input device which accepts at least a given planning problem and values of variables required to solve the given planning problem; a display device which provides a visual display of an optimum plan obtained for the given planning problem; and a planner device which prepares an objective function representing items to be averaged and designs a plan to minimize a value of the objective function. The planner device includes an initial plan reader which reads an initial plan; an objective function value operation unit which calculates an objective function value of the initial plan; a reproduction unit which generates random numbers to a set composed by elements contacting to boundary planes of divided subsets, wherein the random numbers include a range of number of contacting elements and an equally-opportunity-selectable distribution, select at least one element based on the random numbers, equal-opportunity-selecting one of the subsets to which element contacts, and schedule the plan such that the selected element is rendered to belong to the selected subset; a plan renewal unit which compares the objective function value of the current plan with the objective function value of the previous plan to determine the plan having a smaller objective function value as an optimum plan; and a control unit which provides a visual display of an optimum plan on the display device.

摘要翻译： 规划系统包括至少接受给定规划问题的输入设备和解决给定规划问题所需的变量值; 显示装置，其提供针对给定规划问题获得的最佳计划的视觉显示; 以及计划器装置，其准备表示要平均的项目的目标函数，并设计使目标函数的值最小化的计划。 计划器装置包括初始计划读取器，其读取初始计划; 目标函数值运算单元，计算初始计划的目标函数值; 生成随机数的再现单元，其生成由与分割子集的边界面接触的元素组成的集合，其中，所述随机数包括接触元素的数量范围和同等机会选择分布，基于 随机数，等于机会选择元素联系的子集之一，并且调度该计划，使得所选择的元素被归属于所选择的子集; 计划更新单元，其将当前计划的目标函数值与先前计划的目标函数值进行比较，以将具有较小目标函数值的计划确定为最优计划; 以及控制单元，其在所述显示装置上提供最佳计划的视觉显示。

公开(公告)号：US5651098A

公开(公告)日：1997-07-22

申请号：US319789

申请日：1994-10-07

申请人： Haruki Inoue ,  Mayumi Mizutani ,  Hideo Yoshida ,  Hitoshi Onizawa ,  Kenichi Nakamura ,  Yukio Hamaguchi ,  Masami Shiozawa

发明人： Haruki Inoue ,  Mayumi Mizutani ,  Hideo Yoshida ,  Hitoshi Onizawa ,  Kenichi Nakamura ,  Yukio Hamaguchi ,  Masami Shiozawa

IPC分类号： G06Q10/04 ,  G06F15/18

CPC分类号： G06Q10/04 ,  Y10S706/922

摘要： A system for making an optimum plan for a given problem at high speed. The system sets a planning problem, etc., prepares an objective function and finalizes a plan for minimizing or maximizing the objective function value, and then stores necessary variables. The system prepares as many parent plans of a first generation as a given number (population), calculates objective function values, sorts plans in descending or ascending order of the objective function values of the plans, when selection numbers are assigned to plans in order of a ratio of the objective function value of each plan to the total of the objective function values of the plans, selects parent plans by using numbers indicated by as many constants as the population determined for each generation as the selection numbers, and replaces two elements, arranged at order positions specified by random numbers, with each other for each of the selected parent plans, to prepare child plans.

摘要翻译： 用于为给定问题高速制定最佳计划的系统。 系统设置规划问题等，准备目标函数，并确定最小化或最大化目标函数值的计划，然后存储必要的变量。 该系统准备与第一代作为给定数量（人口）一样多的父母计划，计算目标函数值，按照计划的目标函数值按降序或升序对计划进行排序，当选择编号按照 每个计划的目标函数值与计划的目标函数值的总和的比率，通过使用由与为每一代确定的群体一样多的常数指示的数字作为选择数来选择父计划，并且替换两个元素， 按照随机数指定的订单位置进行排列，对于每个选定的母计划，彼此分配，以制定子计划。

公开(公告)号：US5989844A

公开(公告)日：1999-11-23

申请号：US132974

申请日：1998-08-12

申请人： Kaoru Shimada ,  Mayumi Mizutani ,  Fumiharu Naganeo

发明人： Kaoru Shimada ,  Mayumi Mizutani ,  Fumiharu Naganeo

IPC分类号： C12Q1/26 ,  G01N33/15 ,  C12Q1/00 ,  C12Q1/02

CPC分类号： C12Q1/26 ,  G01N2333/795 ,  G01N2333/80 ,  G01N2333/90245 ,  G01N2333/9027 ,  Y10S435/963 ,  Y10S435/968

摘要： This invention relates to a method for evaluating the susceptibility of pharmaceutical drugs to metabolism by a specific cytochrome P-450 isozyme, which comprises contacting the sample compound with a reagent composition prepared by adding the specific cytochrome P-450 isozyme to liver microsomes lacking said specific cytochrome P-450 isozyme in a carrier material. More particularly, this invention relates to a useful in vitro quantitative assay for drug metabolism by P-450 isozymes such as CYP2D6, CYP2C19, and CYP2A6. This invention also relates to a reagent composition which is useful for said in vitro assay.

摘要翻译： 本发明涉及用于评估药物对特定细胞色素P-450同功酶代谢的敏感性的方法，其包括将样品化合物与通过将特异性细胞色素P-450同功酶加入到缺少所述特异性的肝微粒体而制备的试剂组合物 细胞色素P-450同功酶载体材料。 更具体地说，本发明涉及由P-450同功酶如CYP2D6，CYP2C19和CYP2A6进行的药物代谢的有用的体外定量测定。 本发明还涉及可用于所述体外测定的试剂组合物。