3-Piperazinyl 1,2,4-benzothiadiazine 1,1-dioxide derivatives their
compositions and method of use
    1.
    发明授权
    3-Piperazinyl 1,2,4-benzothiadiazine 1,1-dioxide derivatives their compositions and method of use 失效
    3-哌嗪基-1,2,4-苯并噻二嗪1,1-二氧化物衍生物的组成和使用方法

    公开(公告)号:US4029780A

    公开(公告)日:1977-06-14

    申请号:US626042

    申请日:1975-10-28

    CPC分类号: C07D417/04

    摘要: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group, and R.sub.2 represents a hydrogen or halogen atom or a trifluoromethyl group,And its pharmaceutically acceptable salt. The compound is prepared by reacting the corresponding 1,2,4-benzothiadiazine 1,1-dioxide with a piperazine compound or alkylating 1,2,4-benzothiadiazine 1,1-dioxide whose corresponding 3-position is substituted by a piperazinyl group. The above compound has superior antihypertensive activity separated from diuretic, antidiuretic and hyperglycemic activities, and is free from side-effects.

    摘要翻译: 式IMA的化合物,其中R 1表示氢原子或低级烷基,R 2表示氢或卤素原子或三氟甲基,以及其药学上可接受的盐。 该化合物通过相应的1,2,4-苯并噻二嗪1,1-二氧化物与相应的3-位被哌嗪基取代的哌嗪化合物或烷基化的1,2,4-苯并噻二嗪1,1-二氧化物反应来制备。 上述化合物具有从利尿,抗利尿和高血糖活性中分离的优异的抗高血压活性,并且没有副作用。