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公开(公告)号：US20100240585A1
公开(公告)日：2010-09-23
申请号：US12499488
申请日：2009-07-08
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The present invention provides methods and compositions for the in vivo engineering of cell surfaces, such as tumor cell surfaces, with one or more immune co-stimulatory polypeptides. The methods, compositions and engineered cells are useful, for example, to stimulate an immune response against the cells. When the engineered cell surfaces are tumor cell surfaces, the methods, compositions and engineered cells are useful for improving a patient's immune response against the cancer and for reducing tumor size and inhibiting tumor growth.
摘要翻译： 本发明提供了用一种或多种免疫共刺激多肽体内工程化细胞表面如肿瘤细胞表面的方法和组合物。 方法，组合物和工程细胞可用于例如刺激针对细胞的免疫应答。 当工程细胞表面是肿瘤细胞表面时，方法，组合物和工程细胞可用于改善患者对癌症的免疫应答和减少肿瘤大小并抑制肿瘤生长。
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公开(公告)号：US09079976B2
公开(公告)日：2015-07-14
申请号：US13227162
申请日：2011-09-07
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
IPC分类号： C07K14/70 , A61K39/00 , A61K45/06 , A61K47/48 , C12N5/00 , A61K39/12 , C07K14/705 , B82Y5/00 , A61K38/00
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
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公开(公告)号：US20120171240A1
公开(公告)日：2012-07-05
申请号：US13227162
申请日：2011-09-07
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
IPC分类号： A61K39/00 , C07K14/77 , C07K14/705 , A61K39/02 , A61P33/00 , A61P35/00 , A61P31/00 , A61P37/04 , A61P31/04 , A61P31/12 , C12N5/078 , A61K39/12
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
摘要翻译： 本发明提供了包含免疫共刺激多肽和抗原或感染剂的缀合物。 缀合物可用于产生或增强针对抗原或感染因子的免疫应答。 本发明还提供用缀合物修饰的免疫细胞，其可用于产生或增强对抗原或感染因子的免疫应答。 本发明还提供了免疫刺激性部分，其包含可用于刺激免疫应答的免疫共刺激多肽。 本发明还提供了治疗或预防感染的免疫治疗方法和方法。
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公开(公告)号：US08017582B2
公开(公告)日：2011-09-13
申请号：US12553770
申请日：2009-09-03
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
IPC分类号： A61K38/16
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
摘要翻译： 本发明提供了包含免疫共刺激多肽和抗原或感染剂的缀合物。 缀合物可用于产生或增强针对抗原或感染因子的免疫应答。 本发明还提供用缀合物修饰的免疫细胞，其可用于产生或增强对抗原或感染因子的免疫应答。 本发明还提供了免疫刺激性部分，其包含可用于刺激免疫应答的免疫共刺激多肽。 本发明还提供了治疗或预防感染的免疫治疗方法和方法。
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公开(公告)号：US20100158936A1
公开(公告)日：2010-06-24
申请号：US12553770
申请日：2009-09-03
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
IPC分类号： A61K39/385 , C07K14/435 , A61K39/00 , C12N5/02
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
摘要翻译： 本发明提供了包含免疫共刺激多肽和抗原或感染剂的缀合物。 缀合物可用于产生或增强针对抗原或感染因子的免疫应答。 本发明还提供用缀合物修饰的免疫细胞，其可用于产生或增强对抗原或感染因子的免疫应答。 本发明还提供了免疫刺激性部分，其包含可用于刺激免疫应答的免疫共刺激多肽。 本发明还提供了治疗或预防感染的免疫治疗方法和方法。
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公开(公告)号：US07598345B2
公开(公告)日：2009-10-06
申请号：US11635066
申请日：2006-12-07
申请人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
发明人： Haval Shirwan , Kutlu G. Elpek , Esma S. Yolcu
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K47/646 , A61K47/665 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55516 , A61K2039/585 , A61K2039/6031 , A61K2039/625 , B82Y5/00 , C07K14/70575 , C12N5/0012 , C12N2710/20034 , C12N2760/16134 , Y02A50/41 , Y02A50/412 , Y02A50/492 , A61K2300/00
摘要： The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
摘要翻译： 本发明提供了包含免疫共刺激多肽和抗原或感染剂的缀合物。 缀合物可用于产生或增强针对抗原或感染因子的免疫应答。 本发明还提供用缀合物修饰的免疫细胞，其可用于产生或增强对抗原或感染因子的免疫应答。 本发明还提供了免疫刺激性部分，其包含可用于刺激免疫应答的免疫共刺激多肽。 本发明还提供了治疗或预防感染的免疫治疗方法和方法。
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