公开(公告)号：US20230312656A1

公开(公告)日：2023-10-05

申请号：US18024538

申请日：2021-09-01

Applicant: Hawaii Biotech, Inc.

Inventor： David E. Clements ,  James T. Senda ,  Jaime S. Horton

IPC: C07K14/005 ,  C12N15/85 ,  A61K39/39 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K14/005 ,  C12N15/85 ,  A61K39/39 ,  A61K39/215 ,  A61P31/14 ,  C12N2770/20022 ,  C12N2770/20034 ,  A61K2039/55572

Abstract: The present invention is directed to the expression and secretion recombinant SARS-CoV-2 spike protein subunits. Various subunits have been designed and expressed as secreted products into the culture medium of transformed insect cell lines. The design of subunits is focused on the production of products that provide the ability to induce focused immune responses without inducing immune enhancing responses. The expressed and purified products are suitable as vaccine candidates to protect against disease caused by SARS-CoV-2.