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1.发明申请ANCESTRAL SERINE PROTEASE COAGULATION CASCADE EXERTS A NOVEL FUNCTION IN EARLY IMMUNE DEFENSE 审中-公开血清丝氨酸蛋白酶凝血酶在早期免疫防御中发挥新的功能公开(公告)号：US20130177547A1
公开(公告)日：2013-07-11
申请号：US13808162
申请日：2011-07-20
IPC分类号： A61K38/45
CPC分类号： A61K38/45
摘要： The present invention relates to blood coagulation factor XIII (FXIII) for treatment and/or prevention of an infection by a microorganism and/or the symptoms associated with said infection, a pharmaceutical composition comprising a pharmaceutically effective amount of said FXIII, a method for the manufacture of a medicament comprising a pharmaceutically effective amount of said FXIII, and a method of treatment comprising administering to a patient in need a pharmaceutically effective amount of said FXIII.
摘要翻译： 本发明涉及用于治疗和/或预防微生物感染和/或与所述感染有关的症状的凝血因子XIII（FXIII），包含药学上有效量的所述FXIII的药物组合物， 制备包含药学上有效量的所述FXIII的药物，以及治疗方法，其包括向需要的患者施用药学有效量的所述FXIII。
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公开(公告)号：US20120316646A1
公开(公告)日：2012-12-13
申请号：US13493191
申请日：2012-06-11
CPC分类号： A61C8/0006 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L31/044 , A61L31/10 , Y10T428/249924
摘要： The invention provides a biocompatible article having a surface comprising collagen fibrils attached to said surface via one or more linker molecules, wherein each of said collagen fibrils is attached to at least one of said one or more linker molecules at a proximal end of the fibril, and wherein each of said collagen fibril has a proximal portion extending from said proximal end to a point P along said fibril, wherein, for a majority of said fibrils, each fibril at said point P is oriented so as to form an angle αP in the range of 0° to 45° to the surface normal N at the point of attachment of said fibril to said surface. The collagen fibril-coated surface has improved biocompatibility and is useful in a medical implant intended for implantation into soft tissue or bone tissue.
摘要翻译： 本发明提供了一种生物相容性制品，其具有包含通过一个或多个连接分子连接到所述表面的胶原原纤维的表面，其中所述胶原原纤维中的每一个在原纤维的近端连接到所述一个或多个接头分子中的至少一个， 并且其中每个所述胶原纤维具有从所述近端延伸到沿着所述原纤维的点P的近端部分，其中对于所述原纤维的大部分，所述点P处的每个原纤维定向成在所述原纤维中形成角度αP 在所述原纤维附着于所述表面的点处，与表面法线N成0°至45°的范围。 胶原纤维涂覆的表面具有改善的生物相容性，并且可用于植入软组织或骨组织的医用植入物中。
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公开(公告)号：US09295531B2
公开(公告)日：2016-03-29
申请号：US13493191
申请日：2012-06-11
IPC分类号： A61F2/02 , B32B9/00 , C07K14/78 , A61F2/28 , A61C8/02 , A61L27/24 , A61L27/34 , A61L31/04 , A61L31/10
CPC分类号： A61C8/0006 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L31/044 , A61L31/10 , Y10T428/249924
摘要： The invention provides a biocompatible article having a surface comprising collagen fibrils attached to said surface via one or more linker molecules, wherein each of said collagen fibrils is attached to at least one of said one or more linker molecules at a proximal end of the fibril, and wherein each of said collagen fibril has a proximal portion extending from said proximal end to a point P along said fibril, wherein, for a majority of said fibrils, each fibril at said point P is oriented so as to form an angle αP in the range of 0° to 45° to the surface normal N at the point of attachment of said fibril to said surface. The collagen fibril-coated surface has improved biocompatibility and is useful in a medical implant intended for implantation into soft tissue or bone tissue.
摘要翻译： 本发明提供了一种生物相容性制品，其具有包含通过一个或多个连接分子连接到所述表面的胶原原纤维的表面，其中所述胶原原纤维中的每一个在原纤维的近端连接到所述一个或多个接头分子中的至少一个， 并且其中每个所述胶原纤维具有从所述近端延伸到沿着所述原纤维的点P的近端部分，其中对于所述原纤维的大部分，所述点P处的每个原纤维定向成在所述原纤维中形成角度αP 在所述原纤维附着于所述表面的点处，与表面法线N成0°至45°的范围。 胶原纤维涂覆的表面具有改善的生物相容性，并且可用于植入软组织或骨组织的医用植入物中。
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