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公开(公告)号：US09889227B2
公开(公告)日：2018-02-13
申请号：US12299010
申请日：2008-07-08
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： A bone implant for implantation into bone tissue includes a metallic material having a surface that is covered by an oxide layer wherein the oxide layer has a thickness within the range of from 2 to 100 nm and includes strontium ions homogenously dispersed in the oxide layer. The oxide layer is a metal oxide layer formed from the metallic surface of the implant. The local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in the bone tissue.
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公开(公告)号：US20100174382A1
公开(公告)日：2010-07-08
申请号：US12299010
申请日：2008-07-08
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue.In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof.A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锶离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 具体地说，本发明涉及具有由包含锶离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锶离子的喷砂粉末，局部增加骨形成的方法，以及使用锶离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US09744263B2
公开(公告)日：2017-08-29
申请号：US13591147
申请日：2012-08-21
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
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公开(公告)号：US09295531B2
公开(公告)日：2016-03-29
申请号：US13493191
申请日：2012-06-11
IPC分类号： A61F2/02 , B32B9/00 , C07K14/78 , A61F2/28 , A61C8/02 , A61L27/24 , A61L27/34 , A61L31/04 , A61L31/10
CPC分类号： A61C8/0006 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L31/044 , A61L31/10 , Y10T428/249924
摘要： The invention provides a biocompatible article having a surface comprising collagen fibrils attached to said surface via one or more linker molecules, wherein each of said collagen fibrils is attached to at least one of said one or more linker molecules at a proximal end of the fibril, and wherein each of said collagen fibril has a proximal portion extending from said proximal end to a point P along said fibril, wherein, for a majority of said fibrils, each fibril at said point P is oriented so as to form an angle αP in the range of 0° to 45° to the surface normal N at the point of attachment of said fibril to said surface. The collagen fibril-coated surface has improved biocompatibility and is useful in a medical implant intended for implantation into soft tissue or bone tissue.
摘要翻译： 本发明提供了一种生物相容性制品，其具有包含通过一个或多个连接分子连接到所述表面的胶原原纤维的表面，其中所述胶原原纤维中的每一个在原纤维的近端连接到所述一个或多个接头分子中的至少一个， 并且其中每个所述胶原纤维具有从所述近端延伸到沿着所述原纤维的点P的近端部分，其中对于所述原纤维的大部分，所述点P处的每个原纤维定向成在所述原纤维中形成角度αP 在所述原纤维附着于所述表面的点处，与表面法线N成0°至45°的范围。 胶原纤维涂覆的表面具有改善的生物相容性，并且可用于植入软组织或骨组织的医用植入物中。
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公开(公告)号：US20120316646A1
公开(公告)日：2012-12-13
申请号：US13493191
申请日：2012-06-11
CPC分类号： A61C8/0006 , A61F2310/00982 , A61L27/24 , A61L27/34 , A61L31/044 , A61L31/10 , Y10T428/249924
摘要： The invention provides a biocompatible article having a surface comprising collagen fibrils attached to said surface via one or more linker molecules, wherein each of said collagen fibrils is attached to at least one of said one or more linker molecules at a proximal end of the fibril, and wherein each of said collagen fibril has a proximal portion extending from said proximal end to a point P along said fibril, wherein, for a majority of said fibrils, each fibril at said point P is oriented so as to form an angle αP in the range of 0° to 45° to the surface normal N at the point of attachment of said fibril to said surface. The collagen fibril-coated surface has improved biocompatibility and is useful in a medical implant intended for implantation into soft tissue or bone tissue.
摘要翻译： 本发明提供了一种生物相容性制品，其具有包含通过一个或多个连接分子连接到所述表面的胶原原纤维的表面，其中所述胶原原纤维中的每一个在原纤维的近端连接到所述一个或多个接头分子中的至少一个， 并且其中每个所述胶原纤维具有从所述近端延伸到沿着所述原纤维的点P的近端部分，其中对于所述原纤维的大部分，所述点P处的每个原纤维定向成在所述原纤维中形成角度αP 在所述原纤维附着于所述表面的点处，与表面法线N成0°至45°的范围。 胶原纤维涂覆的表面具有改善的生物相容性，并且可用于植入软组织或骨组织的医用植入物中。
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公开(公告)号：US20120316570A1
公开(公告)日：2012-12-13
申请号：US13591147
申请日：2012-08-21
IPC分类号： B05D5/00 , C01G23/047 , C01F11/02 , A61B17/88
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锶离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 具体地说，本发明涉及具有由包含锶离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锶离子的喷砂粉末，局部增加骨形成的方法，以及使用锶离子或其盐来制造用于局部增加骨形成的药物组合物。
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