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公开(公告)号：US20060165591A1
公开(公告)日：2006-07-27
申请号：US11386640
申请日：2006-03-23
CPC分类号： A61K49/0002 , A61K47/547 , A61K47/6887 , Y10S424/90 , Y10T436/24
摘要： Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
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2.发明授权Calcium chelate and gadolinium pharmaceutical composition and methods of X-ray and NMR imaging 失效钙螯合物和钆药物组合物及X射线和NMR成像方法
公开(公告)号：US5098692A
公开(公告)日：1992-03-24
申请号：US601594
申请日：1990-10-22
CPC分类号： A61K47/48076 , A61K47/48707 , A61K49/0002 , Y10S424/90 , Y10T436/24
摘要： Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
摘要翻译： 描述了改进的含金属络合物的药剂，其作为添加剂含有一种或多种络合剂和/或一种或多种弱金属络合物或其混合物。
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公开(公告)号：US5876695A
公开(公告)日：1999-03-02
申请号：US388902
申请日：1995-02-14
CPC分类号： A61K47/48076 , A61K47/48707 , A61K49/0002 , Y10S424/90 , Y10T436/24
摘要： Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
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4.发明授权Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules 失效使用结合生物分子的螯合顺磁离子增强NMR成像的方法
公开(公告)号：US5021236A
公开(公告)日：1991-06-04
申请号：US20300
申请日：1987-03-02
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid, wherein said chelate complex is bound to a biomolecule.
摘要翻译： 可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物 原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸，其中所述螯合络合物与生物分子结合。
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公开(公告)号：US5595725A
公开(公告)日：1997-01-21
申请号：US330954
申请日：1994-10-28
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US4963344A
公开(公告)日：1990-10-16
申请号：US370139
申请日：1989-06-23
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
摘要翻译： 可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物 原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸。
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7.发明授权Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI 失效含有5或6元环的马可环多氮杂双环化合物，以及MRI的方法
公开(公告)号：US5334371A
公开(公告)日：1994-08-02
申请号：US907929
申请日：1992-07-06
申请人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
发明人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
IPC分类号： A61K49/06 , A61K51/04 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07F5/00 , A61B5/055 , A61K31/44 , C07D225/00
CPC分类号： C07F5/003 , A61K49/06 , A61K51/04 , A61K51/0482 , C07D255/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
摘要翻译： 下文定义的下式I和IV的大环化合物及其与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的诊断和治疗剂。
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8.发明授权Sterile composition comprising a chelate complex for magnetic resonance imaging 失效包含用于磁共振成像的螯合物的无菌组合物
公开(公告)号：US5648063A
公开(公告)日：1997-07-15
申请号：US101811
申请日：1993-08-04
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/16 , A61K51/04 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5560903A
公开(公告)日：1996-10-01
申请号：US462681
申请日：1995-06-05
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07C323/25 , C07D257/02 , C07F9/3817 , C07F9/386 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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10.发明授权Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them 失效含有5或6元环的大环多氮化合物，其制备方法和含有它们的药物介质
公开(公告)号：US5403572A
公开(公告)日：1995-04-04
申请号：US213431
申请日：1994-03-15
申请人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
发明人： Heinz Gries , Bernd Raduchel , Johannes Platzek , Hanns-Joachim Weinmann , Wolf-Rudiger Press , Ulrich Speck
IPC分类号： A61K49/06 , A61K51/04 , C07D255/04 , C07D471/08 , C07D487/08 , C07D498/08 , C07D513/08 , C07F5/00 , A61B5/055 , C07D267/22
CPC分类号： C07F5/003 , A61K49/06 , A61K51/04 , A61K51/0482 , C07D255/04 , C07D471/08 , C07D487/08 , C07D513/08 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： The macrocyclic compounds of the following formula I and IV, defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic and therapeutic agents.
摘要翻译： 下文定义的下式I和IV的大环化合物及其与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的诊断和治疗剂。
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